6398-87-4Relevant articles and documents
One-Pot Generation of Benzynes from Phenols: Formation of Primary Anilines by the Deoxyamination of Phenols
Akai, Shuji,Ikawa, Takashi,Masuda, Shigeaki
, (2020/03/23)
Benzynes were selectively generated in situ from phenols and trapped regioselectively with potassium hexamethyldisilazide to form primary anilines following acidic workup. The direct conversion of a phenolic hydroxyl group into a free amino group is a useful method for the preparation of primary aryl amines that are hard to synthesize by using coupling reactions involving phenol derivatives with ammonia. Whereas reactions of ortho- and meta-substituted phenols produced meta-substituted anilines exclusively, those of para-substituted phenols provided ortho-silylanilines.
Synthesis and biological evaluation of novel synthetic chalcone derivatives as anti-tumor agents targeting Cat L and Cat K
Wang, Yali,Xue, Situ,Li, Ruolan,Zheng, Zhihui,Yi, Hong,Li, Zhuorong
, p. 8 - 16 (2017/12/26)
A series of chalcone derivatives bearing benzamide or benzenesulfonamide moieties were synthesized and evaluated for their anti-tumor effect on HCT116, MCF7 and 143B cell lines in vitro. SAR analysis showed that compounds bearing a benzenesulfonamide grou
Synthesis of novel quinoline–based 4,5–dihydro–1H–pyrazoles as potential anticancer, antifungal, antibacterial and antiprotozoal agents
Ramírez–Prada, Jonathan,Robledo, Sara M.,Vélez, Iván D.,Crespo, María del Pilar,Quiroga, Jairo,Abonia, Rodrigo,Montoya, Alba,Svetaz, Laura,Zacchino, Susana,Insuasty, Braulio
, p. 237 - 254 (2017/03/22)
A new series of N–substituted 2–pyrazolines 9a–f, 10a–f, 11a–f, 12a–f and 13a–f were obtained from the cyclocondensation reaction of [(7–chloroquinolin–4–yl)amino]chalcones 8a–f with hydrazine hydrate and its derivatives. Fourteen of the synthesized compo
