64019-93-8 Usage
Description
Dipivefrin hydrochloride, also known as the hydrochloride salt of dipivefrin, is an anti-glaucoma prothrombotic drug that is hydrolyzed to its active compound, epinephrine, by esterases in the cornea. It is characterized by its white or almost white crystalline powder appearance and is recognized for its effectiveness in reducing intraocular pressure.
Uses
Used in Ophthalmology:
Dipivefrin hydrochloride is used as an anti-glaucoma agent for the treatment of open-angle glaucoma or ocular hypertension. It functions by reducing intraocular pressure, which helps to prevent optic nerve damage and slow the progression of glaucoma.
Used in Adrenergic Ophthalmic Treatments:
As an adrenergic ophthalmic agent, dipivefrin hydrochloride is utilized to stimulate the adrenergic receptors in the eye, leading to a decrease in the production of aqueous humor and an increase in uveoscleral outflow. This dual action contributes to the reduction of intraocular pressure, making it a valuable component in the management of glaucoma and ocular hypertension.
Brand Names:
Dipivefrin hydrochloride is available under various brand names, including Akpro (Akorn) and Propine (Allergan), which are used for the treatment of glaucoma and ocular hypertension.
in vivo
Dipivefrin hydrochloride (0.3-10 μg/kg; i.p.;) induces enhancement of memory involves central beta- but not alpha-adrenergic mechanisms.
Check Digit Verification of cas no
The CAS Registry Mumber 64019-93-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,0,1 and 9 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 64019-93:
(7*6)+(6*4)+(5*0)+(4*1)+(3*9)+(2*9)+(1*3)=118
118 % 10 = 8
So 64019-93-8 is a valid CAS Registry Number.
InChI:InChI=1/C19H29NO5.ClH/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6;/h8-10,13,20-21H,11H2,1-7H3;1H
64019-93-8Relevant articles and documents
Enantiomeric separation and simulation study of eight anticholinergic drugs on an immobilized polysaccharide-based chiral stationary phase by HPLC
Li, Meng,Zhang, Bo,Yu, Jia,Wang, Jian,Guo, Xingjie
, p. 11724 - 11731 (2018/07/25)
The enantiomeric separation of eight anticholinergic drugs was first systematically examined on a derivative polysaccharide chiral stationary phase (CSP), i.e. Chiralpak ID in the normal phase mode. Except for scopolamine hydrobromide and benzhexol hydroc
