64022-27-1

Basic information

• Product Name: MK 212 HYDROCHLORIDE
• Synonyms: MK 212 HYDROCHLORIDE;6-CHLORO-2-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE;6-CHLORO-2-(1-PIPERAZINYL)PYRAZINE;MK212HCl;MK 212;2-CHLORO-6-(PIPERAZIN-1-YL)PYRAZINE, MK212;2-Chloro-6-(1-piperazinyl)pyrazine;2-Chloro-6-(Piperazin-1-Yl)Pyrazine
• CAS NO: 64022-27-1
• Molecular Formula: C₈H₁₁ClN₄
• Molecular Weight: 235.11
• Product Categories: Serotonin receptor
• Mol File: 64022-27-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 364.1 °C at 760 mmHg
• Flash Point: 174 °C
• Appearance: /
• Density: 1.272 g/cm³
• Storage Temp.: Store at RT
• CAS DataBase Reference: MK 212 HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: MK 212 HYDROCHLORIDE(64022-27-1)
• EPA Substance Registry System: MK 212 HYDROCHLORIDE(64022-27-1)

Safety Data

• Hazardous Substances Data: 64022-27-1(Hazardous Substances Data)

Usage

Description

MK 212 Hydrochloride, also known as 1-(3-trifluoromethylphenyl)piperazine hydrochloride, is a synthetic compound that acts as a selective agonist for the 5-HT2C serotonin receptor. It is a white to off-white crystalline powder with a chemical formula of C18H20F3N3·HCl. MK 212 Hydrochloride has been studied for its potential therapeutic effects in various medical applications, particularly in the treatment of stress-related disorders and as a possible antipsychotic agent.

Uses

Used in Pharmaceutical Industry:
MK 212 Hydrochloride is used as an anti-stress treatment for its ability to selectively activate the 5-HT2C serotonin receptor. This activation is believed to help alleviate stress and anxiety by modulating the serotonin levels in the brain, leading to a calming effect on the central nervous system.
Used in Research and Development:
MK 212 Hydrochloride is used as a research compound for studying the role of the 5-HT2C receptor in various physiological and pathological processes. It can be employed in preclinical studies to investigate the potential therapeutic effects of 5-HT2C agonism in conditions such as depression, anxiety, and other stress-related disorders.
Used in Antipsychotic Drug Development:
MK 212 Hydrochloride is used as a potential antipsychotic agent due to its selective agonist activity at the 5-HT2C receptor. It is being investigated for its ability to alleviate symptoms of psychotic disorders, such as schizophrenia, by modulating the serotonin signaling pathways in the brain.

Biological Activity

5-HT 2C serotonin receptor agonist.

Upstream product

• 110-85-0 piperazine 
• 4774-14-5 2,6-dichloropyrazine 
• 426829-52-9 tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate 

Downstream Products

• 1006699-36-0 (E)-3-[3-(3,4,5,6-Tetrahydro-2H-[1,2']bipyrazinyl-6'-yl)phenyl]acrylic acid 

Relevant articles and documents

Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors

Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimization of the C-3 and C-5 positions of indole yielded compound 43 with improved cellular potency and high selectivity against a panel of 14 different kinases.

Hit to lead account of the discovery of a new class of inhibitors of pim kinases and crystallographic studies revealing an unusual kinase binding mode

A series of inhibitors of Pim-2 kinase identified by high-throughput screening is described. Details of the hit validation and lead generation process and structure-activity relationship (SAR) studies are presented. Disclosure of an unconventional binding mode for 1, as revealed by X-ray crystallography using the highly homologous Pim-1 protein, is also presented, and observed binding features are shown to correlate with the Pim-2 SAR. While highly selective within the kinase family, the series shows similar potency for both Pim-1 and Pim-2, which was expected on the basis of homology, but unusual in light of reports in the literature documenting a bias for Pim-1. A rationale for these observations based on Pim-1 and Pim-2 KM(ATP) values is suggested. Some interesting cross reactivity with casein kinase-2 was also identified, and structural features which may contribute to the association are discussed.

Piperazinylpyrazines with central serotoninmimetic activity.

A series of 2-(1-piperazinyl)pyrazines was synthesized and evaluated for central serotonin-like activity. The most interesting member of the series, 6-chloro-2(1-piperazinyl)pyrazine (3a), had pharmacological properties characteristic of potent central serotoninmimetic activity and only weak peripheral serotoninmimetic action. Structural similarities between 3a and serotonin are discussed.