64072-89-5 Usage
Description
9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID, also known as Prostaglandin D2 (PGD2), is one of the five primary enzymatic prostaglandins derived directly from PGH2. It is produced in the central nervous system by the lipocalin-type PGD synthase and in the periphery by myeloid cells, including mast cells and basophils, by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable and has a short in vivo half-life, making its use and analysis challenging. Δ12-PGD2 is an intermediate in the pathway leading to Δ12-PGJ2, a cyclopentenone prostaglandin with antimitotic and carcinogenic activities.
Uses
Used in Pharmaceutical Industry:
9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID is used as a pharmaceutical agent for its potential therapeutic applications. Due to its chemical instability and short half-life, research is focused on developing methods to stabilize PGD2 and enhance its bioavailability for use in various medical treatments.
Used in Research and Development:
In the field of research and development, 9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID is used as a key compound in studying the metabolism and biological effects of prostaglandins. Understanding the pathways and interactions of PGD2 and its decomposition products, such as Δ12-PGD2 and Δ12-PGJ2, can provide valuable insights into the development of new drugs and therapies.
Used in Drug Metabolism Studies:
9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID is used as a subject in drug metabolism studies to investigate the addition of thiol nucleophiles, a common reaction for cyclopentenone prostaglandins. This research can contribute to the development of new drugs with improved stability and efficacy.
Used in Anticancer Applications:
Although not explicitly mentioned in the provided materials, due to the antimitotic and carcinogenic activities of Δ12-PGJ2, which is derived from PGD2, it is plausible that 9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID could be used as a starting point for the development of anticancer agents. Further research would be required to explore this potential application.
Check Digit Verification of cas no
The CAS Registry Mumber 64072-89-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,0,7 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 64072-89:
(7*6)+(6*4)+(5*0)+(4*7)+(3*2)+(2*8)+(1*9)=125
125 % 10 = 5
So 64072-89-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,13,15-16,18,21-22H,2-3,5-6,8-12,14H2,1H3,(H,24,25)/b7-4-,17-13+/t15-,16+,18-/m0/s1
64072-89-5Relevant articles and documents
Synthesis and Platelet Aggregation Inhibiting Activity of Prostaglandin D Analogues
Bundy, Gordon L.,Morton, D. R.,Peterson, D. C.,Nishizawa, E. E.,Miller, W. L.
, p. 790 - 799 (2007/10/02)
Several prostaglandin D (PGD) analogues have been synthesized, incorpotating the following variations: (a) varying degrees of side-chain unsaturation, (b) C-9 hydroxy removed or in the unnatural 9β configuration, (c) metabolically stabilized analogues (e.
