641-77-0Relevant articles and documents
TRANSFORMED STEROIDS. 188. SYNTHESIS ROUTES FOR 11β-HYDROXY-SUBSTITUTED 16-DEHYDRO-, 17β-HYDROXY- AND 16α,17α-EPOXYPREGNANES BASED ON 17α-ETHYNYL-11β-DIHYDROXYANDROSTANES
Turuta, A. M.,Fadeeva, T. M.,Kamernitskii, A. V.
, p. 285 - 289 (1992)
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Dehalogenation methodof 9-halogenated steroid compound and application
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Paragraph 0194-0196, (2021/01/11)
The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.
REDUCTIVE DEHALOGENATION OF 21-IODO DERIVATIVES OF CORTICOSTEROIDS
Mikhal'chuk, A. L.,Pschenichnyi, V. N.
, p. 1479 - 1485 (2007/10/02)
In the reactions of 21-iodo derivatives of corticosteroids with hydrogen sulfide and thiol-containing reagents in a medium of dipolar aprotic and amide protogenic solvents at room temperature reductive-deiodination reactions occur with the formation of 21-deoxycorticosteroids in quantitative yield.Reactions of solutions of 21-iodomethyl ketones, heated to 80 deg C, with hydrogen sulfide and thiol-containing reagents give not only reduction products, but also products of nucleophilic substitution at C21 in yields of 20-30percent.