64146-72-1

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 5-[(4-methylphenyl)thio]-
• CAS NO: 64146-72-1
• Molecular Formula: C15H11NO2S
• Molecular Weight: 269.324
• Mol File: 64146-72-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 5-[(4-methylphenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 5-[(4-methylphenyl)thio]-(64146-72-1)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 5-[(4-methylphenyl)thio]-(64146-72-1)

Safety Data

• Hazardous Substances Data: 64146-72-1(Hazardous Substances Data)

Upstream product

• 6941-75-9 5-Bromoisoindoline-1,3-dione 
• 106-45-6 para-thiocresol 
• 85-44-9 phthalic anhydride 
• 86-90-8 4-bromophthalic anhydride 
• 6968-28-1 4-bromophthalic acid 

Relevant articles and documents

Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2

We report herein characteristic studies of Mcl-1 and Bcl-2 dual inhibitors. It was found that a protruding carbonyl group forming hydrogen bond with R263 plays a predominant role compared with the hydrophobic group that occupies the p2 pocket. A series of dual inhibitors representing different parts of the morpholino-1H-phenalene were designed, synthesized and evaluated.