64172-98-1

Basic information

• Product Name: N-4-CBZ-2-PIPERAZINECARBOXYLIC ACID
• Synonyms: 4-CBZ-2-PIPERAZINECARBOXYLIC ACID;4-CBZ-PIPERAZINE-2-(+/-)-CARBOXYLIC ACID;4-CBZ-PIPERAZINE-2-CARBOXYLIC ACID;4-N-CBZ-2-PIPERAZINE CARBOXYLIC ACID;PIPERAZINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER;N-4-CBZ-2-PIPERAZINECARBOXYLIC ACID;Piperazine-2-carboxylic acid, N4-CBZ protected;1-BENZYL-1,3-PIPERAZINEDICARBOXYLIC ACID
• CAS NO: 64172-98-1
• Molecular Formula: C₁₃H₁₆N₂O₄
• Molecular Weight: 264.28
• Product Categories: pharmacetical
• Mol File: 64172-98-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 465.1 °C at 760 mmHg
• Flash Point: 235.1 °C
• Appearance: /
• Density: 1.294 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.20±0.20(Predicted)
• CAS DataBase Reference: N-4-CBZ-2-PIPERAZINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-4-CBZ-2-PIPERAZINECARBOXYLIC ACID(64172-98-1)
• EPA Substance Registry System: N-4-CBZ-2-PIPERAZINECARBOXYLIC ACID(64172-98-1)

Safety Data

• Hazardous Substances Data: 64172-98-1(Hazardous Substances Data)

Usage

General Description

N-4-CBZ-2-piperazinecarboxylic acid, also known as N-carbobenzoxy-2-piperazinecarboxylic acid, is a chemical compound that belongs to the class of piperazines, which are organic compounds containing the heterocyclic structure of two nitrogen atoms and four carbon atoms. N-4-CBZ-2-PIPERAZINECARBOXYLIC ACID has a carboxylic acid functional group and a benzoyl (CBZ) protecting group attached to the nitrogen atom. It is often used as a precursor in the synthesis of various pharmaceuticals and is also utilized in the field of organic chemistry as a building block for the construction of more complex molecules. Additionally, it has been investigated for its potential biological activities, including antifungal and anticonvulsant properties. Overall, N-4-CBZ-2-piperazinecarboxylic acid plays an important role in drug development and chemical research.

Upstream product

• 2762-32-5 piperazine-2-carboxylic acid 
• 1885-14-9 phenyl chloroformate 
• 3022-15-9 piperazine-2-carboxylic acid dihydrochloride 
• 7758-99-8 copper(II) sulfate 
• 1214196-85-6 1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid 
• 501-53-1 benzyl chloroformate 
• 149057-19-2 4-((benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid 

Downstream Products

• 276695-15-9 4-Carbobenzyloxy-1-(5,6-Dichloro-2-Nitrophenyl)-Piperazine-2-Carboxylic Acid 
• 304023-12-9 4-(2-chloro-6-nitro-phenyl)-piperazine-1,3-dicarboxylic acid 1-benzyl ester 
• 276695-07-9 4-carbobenzyloxy-1-(4,5-dichloro-2-nitrophenyl)piperazine-2-carboxylic acid 
• 276695-19-3 4-carbobenzyloxy-1-(4,5-difluoro-2-nitrophenyl)-piperazine-2-carboxylic acid 
• 304023-21-0 4-(3,5-dichloro-2-nitro-phenyl)-piperazine-1,3-dicarboxylic acid 1-benzyl ester 
• 276695-31-9 4-(5-chloro-2-nitro-4-trifluoromethyl-phenyl)-piperazine-1,3-dicarboxylic acid 1-benzyl ester 
• 64182-68-9 4-carbobenzoxy-1-(5-chloro-2-nitrophenyl)piperazine-2-carboxylic acid 
• 304023-14-1 4-(5-fluoro-2-nitro-phenyl)-piperazine-1,3-dicarboxylic acid 1-benzyl ester 
• 304023-13-0 4-(5-hydroxy-2-nitro-phenyl)-piperazine-1,3-dicarboxylic acid 1-benzyl ester 
• 64182-55-4 4-carbobenzoxy-1-(5-methoxy-2-nitrophenyl)piperazine-2-carboxylic acid 
• 64182-77-0 4-carbobenzoxy-1-(5-methyl-2-nitrophenyl)piperazine-2-carboxylic acid 
• 304023-17-4 4-(4-amino-2-nitro-phenyl)-piperazine-1,3-dicarboxylic acid 1-benzyl ester 
• 64182-58-7 4-carbobenzyloxy-l-(4-chloro-2-nitrophenyl)piperazine-2-carboxylic acid 
• 304023-16-3 4-(4-carbamoyl-2-nitro-phenyl)-piperazine-1,3-dicarboxylic acid 1-benzyl ester 

Relevant articles and documents

HEPATITIS B CAPSID ASSEMBLY MODULATORS

Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonist and antagonists ligands

The present invention is directed to novel compounds represented by structural Formulas (I) and (I-a): or a pharmaceutically acceptable salt thereof, wherein R1, R4a, R4b, R5, R6, R7, R8, R9, n, and X are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep and sexual disorders, migraine and other conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.