6420-90-2

Basic information

• Product Name: Ethanone, 2-(4-hydroxyphenyl)-1-phenyl-
• CAS NO: 6420-90-2
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• Mol File: 6420-90-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(4-hydroxyphenyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(4-hydroxyphenyl)-1-phenyl-(6420-90-2)
• EPA Substance Registry System: Ethanone, 2-(4-hydroxyphenyl)-1-phenyl-(6420-90-2)

Safety Data

• Hazardous Substances Data: 6420-90-2(Hazardous Substances Data)

Upstream product

• 123540-69-2 α-(4-Hydroxyphenoxy)acetophenone 
• 106-51-4 p-benzoquinone 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 38469-73-7 1-(4-hydroxyphenyl)-2-phenylethan-1,2-dione 
• 2648-61-5 2,2-dichloroacetophenone 
• 14191-95-8 4-cyanomethylphenol 
• 98-80-6 phenylboronic acid 
• 24845-40-7 2-(4-methoxyphenyl)acetophenone 
• 98-86-2 acetophenone 

Downstream Products

• 153822-78-7 3,5-dibromo-4-hydroxybenzyl phenyl ketone 
• 94348-37-5 (E)-2,3-Bis-(4-hydroxy-phenyl)-1-phenyl-propenone 
• 94348-38-6 (Z)-2,3-Bis-(4-hydroxy-phenyl)-1-phenyl-propenone 
• 914490-66-7 2-[4-(7-hydroxy-6-methoxy-quinolin-4-yloxy)-phenyl]-1-phenyl-ethanone 
• 914490-67-8 (S)-2-tert-butoxycarbonylamino-4-{6-methoxy-4-[4-(2-oxo-2-phenyl-ethyl)-phenoxy]-quinolin-7-yloxy}-butyric acid cyclopentyl ester 
• 938-96-5 2-(4-Hydroxy-phenyl)-propionic acid 
• 134994-76-6 2-[4-[[6-(dimethylamino)hexyl]oxy]phenyl]acetophenone 
• 35263-89-9 2-[4-(2-Diethylamino-ethoxy)-phenyl]-1-(4-methoxy-phenyl)-1-phenyl-ethanol 
• 144883-03-4 (Z)-1-acetoxy-1-phenyl-2-(4-methoxyphenyl)ethene 

Relevant articles and documents

The Ligand Free Palladium(II)-Catalyzed Regioselective 1,2-Addition of Enol Silanes to Quinones to Access 4-Hydroxy-4-(2-oxo-2-arylethyl)cyclohexadien-1-ones and Synthetic Applications

In contrast to the conventional 1,4-addition process, regioselective 1,2-addition of silyl enol ethers to quinones can now be achieved via a palladium(II) enolate pathway that provides access to 4-hydroxy-4-(2-oxo-2-arylethyl)cyclohexa-2,5-dien-1-one derivatives. This quinone alkylation protocol proceeds under mild reaction conditions at ambient temperature under open air and does not require either an external ligand for the palladium or the use of a base. Additionally, the cyclohexadienone products have been exploited as synthetic precursors for the construction of fused heteroaryl systems.

Cu-Catalyzed Stereoselective γ-Alkylation of Enones

A general regio- and stereoselective γ-C-C bond formation is achieved using α-halocarbonyl compounds and dienol ethers via Cu(II) catalysis. This method constitutes a novel approach to the challenging 1,6-dioxygenation motif. A range of γ-substituted enones, including many bearing all-carbon quaternary centers, are available through a simple protocol under mild reaction conditions with superb functional group compatibility. Excellent stereoinduction is observed providing controlled access to challenging stereochemical arrays.

QUINOLINE AND QUINOXALINE DERIVATIVES AS INHIBITORS OF KINASE ENZYMATIC ACTIVITY

Compounds of formula (IA) or (IB), are inhibitors of aurora kinase activity: Formula (IA), (IB) wherein -L1Y1-[CH2]z- is a linker radical wherein Y1, L1 and z are as defined in the claims; R6 is C1-C4alkoxy, hydrogen or halo; W represents a bond, -CH2-, -O-, -S-, -S(=O)2-, or -NR5- where R5 is hydrogen or C1-C4 alkyl; Q is =N-, =CH- or =C(X1)- wherein X1 is cyano, cyclopropyl or halo; linker radicals L2 are as defined in the claims; R is a radical of formula (X) or (Y): wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, heteroaryl(C1-C6 alkyl)-, -(C=O)R3, -(C=O)OR3, or -(C=O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, or heteroaryl(C1-C6 alkyl)-; R41 is hydrogen or optionally substituted C1-C6 alkyl; and D is a monocyclic heterocyclic ring of 5 or 6 ring atoms.