64214-60-4

Basic information

• Product Name: N-Methoxy-N,2,2-trimethylpropanamide
• Synonyms: N-Methoxy-N,2,2-trimethylpropanamide
• CAS NO: 64214-60-4
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.1995
• Mol File: 64214-60-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 62-64 °C(Press: 10 Torr)
• Appearance: /
• Density: 0.937±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Methoxy-N,2,2-trimethylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methoxy-N,2,2-trimethylpropanamide(64214-60-4)
• EPA Substance Registry System: N-Methoxy-N,2,2-trimethylpropanamide(64214-60-4)

Safety Data

• Hazardous Substances Data: 64214-60-4(Hazardous Substances Data)

Usage

General Description

N-Methoxy-N,2,2-trimethylpropanamide is a chemical compound with the molecular formula C7H15NO2. It is a colorless liquid with a mild, fruity odor. N-Methoxy-N,2,2-trimethylpropanamide is used as a solvent and as a raw material for the synthesis of other chemicals. It is also used in the pharmaceutical industry as an intermediate in the production of various drugs. N-Methoxy-N,2,2-trimethylpropanamide is considered to be relatively stable and non-reactive, making it a useful and versatile compound in various industrial applications. However, it should be handled with care due to its potential to cause skin and eye irritation.

Upstream product

• 60-29-7 diethyl ether 
• 3282-30-2 pivaloyl chloride 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 1062512-43-9 C₆H₁₈N₃O₃P 
• 75-98-9 Trimethylacetic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 

Downstream Products

• 160855-11-8 2,2-Dimethyl-6-tritylsulfanyl-hex-4-yn-3-one 
• 37471-41-3 3,3-dimethyl-1-(phenylthio)butan-2-one 
• 6830-83-7 N-methyl-pivalamide 
• 1423304-35-1 6-benzyl-2-tert-butyl-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 59997-51-2 trimethylacetylacetonitrile 
• 71932-99-5 2,2-dimethylhex-4-yn-3-one 

Relevant articles and documents

Synthesis of (14C)tert-butyl acetylene

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Total Synthesis and Antitrypanosomal Activity of Janadolide and Simplified Analogues

Janadolide is a cyclic depsipeptide natural product isolated from the marine cyanobacterium Okeania sp. Herein, we describe the total synthesis of janadolide, along with eight simplified analogues, via an efficient solid-phase strategy. Crucial to the synthesis of the natural product was the construction of a key polyketide fragment via an enantioselective (-)-B-chlorodiisopinocampheylborane-mediated reduction and a B-alkyl Suzuki reaction. Janadolide and the simplified analogues exhibited antitrypanosomal activity against pathogenic Trypanosoma brucei rhodesiense and Trypanosoma cruzi parasites.

One-pot transition-metal-free synthesis of weinreb amides directly from carboxylic acids

Weinreb amides were prepared directly from carboxylic acids, N,O-dimethylhydroxylamine, and phosphorus trichloride in one pot at 60 °C in toluene in high yields, thus avoiding the separation of the moisture and air sensitive intermediate P[NMe(OMe)]3 in advance. Sterically hindered carboxylic acids also give the corresponding Weinreb amides in excellent yields. Various functional groups are tolerated on the carboxylic acid. The method, which is a simple process and gives high yields, is suitable for large-scale production. Georg Thieme Verlag KG Stuttgart · New York.