64228-79-1 Usage
Description
5-[3-[1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-yl]propanoate is a complex organic compound with a unique molecular structure. It is characterized by the presence of multiple methoxy and methyl groups, as well as a propanoate functional group. 5-[3-[1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-yl]propanoate has potential applications in various fields due to its unique properties.
Uses
Used in Pharmaceutical Industry:
5-[3-[1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-yl]propanoate is used as a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs. It is used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Used in Drug Delivery Systems:
5-[3-[1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-yl]propanoate can be used in drug delivery systems to improve the delivery, bioavailability, and therapeutic outcomes of various drugs. Its unique molecular structure allows for the development of novel drug delivery systems, such as organic and metallic nanoparticles, which can enhance the efficacy of the compound in treating various conditions.
Pharmacokinetics
Atracurium besylate, a new non-depolarizing neuromuscular blocking agent, with short to intermediary duration of action and no significant cardiovascular effects. Not dependent on kidney function for elimination, it provides clinical advantages over other non-depolarizing, neuromuscular blocking agents. In vitro, in human plasma, the half-life of the drug was similar to that in buffer at the same pH being approximately 25 min (Hughes and Chappie, 1980).
Synthesis
Atracurium is 2,2-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]] bis
[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]
dibenzene sulfonate (15.1.12). This compound is synthesized from bis-acrylic
ester of 1,5-pentandiol (15.1.10), which is synthesized from acrylic acid chloride and 1,
5-pentandiol. Two molecules of a secondary amine, tetrahydropapaverine, are joined to the
product in a Michael reaction, forming compound (15.1.11). Then both nitrogen atoms are
methylated by methylbenzenesulfonate, giving atracurium (15.1.12).
Metabolism
Atracurium besylate is a nondepolarizing neuromuscular blocker in which the quaternary ammonium groups are located in two substituted
tetrahydroisoquinoline rings separated by an aliphatic diester. It has a duration of action slightly longer than that of succinylcholine. Atracurium
is not metabolized in the liver; rather, it undergoes hydrolysis of the ester functional groups that connect the two quaternary nitrogens. It also
undergoes Hofmann elimination, a nonenzymatic, base-catalyzed decomposition, to yield laudanosine, which is inactive.
T hus, termination of the effects of atracurium are independent of renal elimination. Because of this unusual metabolic profile, it is useful in
patients with hepatic or renal disease.
Check Digit Verification of cas no
The CAS Registry Mumber 64228-79-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,2,2 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 64228-79:
(7*6)+(6*4)+(5*2)+(4*2)+(3*8)+(2*7)+(1*9)=131
131 % 10 = 1
So 64228-79-1 is a valid CAS Registry Number.
InChI:InChI=1/C53H72N2O12/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3/q+2/t42-,43-,54-,55-/m1/s1