642444-30-2 Usage
General Description
2-(3-trifluoromethoxyphenyl)ethanol, also known under the trade name Tramadol, is a chemical compound with a molecular structure consisting of a benzene ring attached to an ethyl group with a hydroxyl (alcohol) functional group. 2-(3-TRIFLUOROMETHOXYPHENYL)ETHANOL is commonly used as a pain reliever and is classified as a synthetic opioid analgesic. Tramadol works by binding to opioid receptors in the brain and spinal cord, effectively blocking the transmission of pain signals. Its trifluoromethoxy group enhances the compound's affinity for opioid receptors, contributing to its analgesic effects. Tramadol is also a central nervous system depressant, and it can have various side effects, including dizziness, nausea, and respiratory depression. Due to its potential for abuse and addiction, tramadol is classified as a controlled substance in many countries.
Check Digit Verification of cas no
The CAS Registry Mumber 642444-30-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,4,2,4,4 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 642444-30:
(8*6)+(7*4)+(6*2)+(5*4)+(4*4)+(3*4)+(2*3)+(1*0)=142
142 % 10 = 2
So 642444-30-2 is a valid CAS Registry Number.
642444-30-2Relevant articles and documents
2-, 3-, and 4-(Trifluoromethoxy)phenyllithiums: Versatile intermediates offering access to a variety of new organofluorine compounds
Castagnetti, Eva,Schlosser, Manfred
, p. 691 - 695 (2007/10/03)
Consecutive treatment of (trifluoromethoxy)benzene with sec-butyllithium and electrophilic reagents affords previously inaccessible ortho-substituted derivatives in generally excellent yields. 2-(Trifluoromethoxy)phenyllithium acts as the key intermediate. The 3- and 4-isomers can readily be generated from the corresponding 3- and 4-bromo precursors by halogen-metal interconversion with butyllithium or tertbutyllithium. Upon trapping of the 2-, 3- and 4-(trifluoromethoxy)phenyllithiums with 11 different electrophiles the expected products were formed in generally high yields. Only the attempted nucleophilic addition of 2-(trifluoromethoxy)phenyllithium to oxirane did not succeed. This failure is tentatively attributed to a lowering of the nucleophilicity by fluorine-lithium interactions. Conformationally restricted analogs - i.e., 2,2-difluoro-1,3-benzodioxol-4-phenyllithium and its 5-fluoro- and 5-bromo-substituted congeners - did indeed react smoothly with oxirane, affording the adducts in ordinary yields.
