64277-86-7Relevant articles and documents
Nickel-Catalyzed Reductive Coupling of Aryl Bromides with Tertiary Alkyl Halides
Wang, Xuan,Wang, Shulin,Xue, Weichao,Gong, Hegui
, p. 11562 - 11565 (2015)
A mild Ni-catalyzed reductive arylation of tertiary alkyl halides with aryl bromides has been developed that delivers products bearing all-carbon quaternary centers in moderate to excellent yields with excellent functional group tolerance. Electron-deficient arenes are generally more effective in inhibiting alkyl isomerization. The reactions proceed successfully with pyridine or 4-(dimethylamino)pyridine, while imidazolium salts slightly enhance the coupling efficiency.