64282-12-8

Basic information

• Product Name: H-P-FLUORO-DL-PHE-OME HCL
• Synonyms: H-DL-PHE(4-F)-OME HCL;H-P-FLUORO-DL-PHE-OME HCL;4-FLUORO-DL-PHENYLALANINE METHYL ESTER HYDROCHLORIDE;P-FLUORO-DL-PHENYLALANINE-OME HCL;H-p-Fluoro-DL-Phe-OMe;H-p-fluoro-DL-Phe-OMe hydrochloride;(RS)-2-amino-3-(4-fluorophenyl)propionic acid;4-Fluoro-DL-phenylalanine methyl ester hydrochloride98+%
• CAS NO: 64282-12-8
• Molecular Formula: C₁₀H₁₂FNO₂*ClH
• Molecular Weight: 233.67
• Mol File: 64282-12-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 176.5-178.5 °C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: H-P-FLUORO-DL-PHE-OME HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-P-FLUORO-DL-PHE-OME HCL(64282-12-8)
• EPA Substance Registry System: H-P-FLUORO-DL-PHE-OME HCL(64282-12-8)

Safety Data

• Hazardous Substances Data: 64282-12-8(Hazardous Substances Data)

Usage

Uses

H-P-Fluoro-DL-Phe-OMe HCl

Upstream product

• 67-56-1 methanol 
• 51-65-0 4-Fluorophenylalanine 

Downstream Products

• 143051-63-2 (R)-4-fluoro-N-benzoyl-phenylalanine methylester 
• 143051-64-3 (S)-4-fluoro-N-benzoyl-phenylalanine methylester 
• 133919-66-1 4-fluoro-(RS)-phenylalaninamide hydrochloride 
• 1132-68-9 L-4-fluorophenylalanine 
• 18125-46-7 (R)-4-fluorophenylalanine 

Relevant articles and documents

A new type of chiral-pyridoxamines for catalytic asymmetric transamination of α-keto acids

A new type of chiral pyridoxamines bearing an adjacent chiral stereocenter has been developed via multi-step synthesis. The pyridoxamines displayed catalytic activity in asymmetric transamination of α-keto acids to give a variety of optically active amino acids in 27–78% yields with 34–62% ee's under very mild conditions. This work provides a synthetic strategy to construct new chiral pyridoxamines using bromopyridine 7 as a key synthon and also represents an early example of the applications of chiral pyridoxamines in asymmetric catalysis.

Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities

Protein tyrosine phosphatase 1B is a key factor in the negative regulation of insulin pathway and a promising target for treatment of diabetes and obesity. Herein, a series of competitive inhibitors were optimized from oleanolic acid, a natural triterpenoid identified against PTP1B by screening libraries of traditional Chinese medicinal herbs. Modifying at 3 and 28 positions, we obtained compound 13 with a Ki of 130 nM, which exhibited good selectivity between other phosphatases involved in insulin pathway except T-cell protein tyrosine phosphatase. Further evaluation in cell models illustrated that the derivatives enhanced insulin receptor phosphorylation in CHO/hIR cells and also stimulated glucose uptake in L6 myotubes with or addition of without insulin.

Resolution of non-protein amino acids via the microbial protease-catalyzed enantioselective hydrolysis of their N-unprotected esters

In the Aspergillus oryzae protease-catalyzed ester hydrolysis, substitution of N-unprotected amino acid esters for the corresponding N-protected amino acid esters resulted in a large enhancement of the hydrolysis rate, while the enantioselectivity was deteriorated strikingly when the substrates employed were the conventional methyl esters. This difficulty was overcome by employing esters bearing a longer alkyl chain such as the isobutyl ester. Utilizing this ester, amino acids carrying an aromatic side chain were resolved with excellent enantioselectivities (E=50 to >200). With amino acids bearing an aliphatic side chain also, good results in terms of the hydrolysis rate and enantioselectivity were obtained by employing such an ester as the isobutyl ester. Moreover, the enantioselectivity proved to be enhanced further by conducting the reaction at low temperature. This procedure was applicable to the case where the enantioselectivity was not high enough even by the use of the isobutyl ester.