643044-04-6

Basic information

• Product Name: METHYL 4,7-DICHLORO-QUINOLINE-2-CARBOXYLATE
• Synonyms: METHYL 4,7-DICHLORO-QUINOLINE-2-CARBOXYLATE;2-Quinolinecarboxylic acid, 4,7-dichloro-, methyl ester;4,7-Dichloro-2-quinolinecarboxylic acid methyl ester
• CAS NO: 643044-04-6
• Molecular Formula: C11H7Cl2NO2
• Molecular Weight: 256.08
• Mol File: 643044-04-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 377.3 °C at 760 mmHg
• Flash Point: 182 °C
• Appearance: /
• Density: 1.434
• CAS DataBase Reference: METHYL 4,7-DICHLORO-QUINOLINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4,7-DICHLORO-QUINOLINE-2-CARBOXYLATE(643044-04-6)
• EPA Substance Registry System: METHYL 4,7-DICHLORO-QUINOLINE-2-CARBOXYLATE(643044-04-6)

Safety Data

• Hazardous Substances Data: 643044-04-6(Hazardous Substances Data)

Usage

General Description

Methyl 4,7-dichloro-quinoline-2-carboxylate is a chemical compound with the molecular formula C12H8Cl2NO2. It is a synthetic organic compound that belongs to the quinoline family and is commonly used in the pharmaceutical industry. METHYL 4,7-DICHLORO-QUINOLINE-2-CARBOXYLATE has a range of potential applications, including as a building block for the synthesis of other chemical compounds and as a precursor in the production of pharmaceutical drugs. Methyl 4,7-dichloro-quinoline-2-carboxylate may also have biological activity that could make it useful in the development of new medications. However, it is important to handle this compound with care, as it may be harmful if not properly handled and used.

Upstream product

• 5347-19-3 methyl 7-chloro-4-hydroxy-2-quinolinecarboxylate 
• 108-42-9 3-chloro-aniline 
• 762-42-5 dimethyl acetylenedicarboxylate 

Relevant articles and documents

Synthesis and in vitro anticancer activity of ferrocenyl-aminoquinoline- carboxamide conjugates

The syntheses and characterization of new multifunctional aminoquinoline-carboxamides and their ferrocene derivatives are reported, as well as their cytotoxicity against human colon adenocarcinoma (Caco-2, HTB-37), human breast carcinoma (HTB-129) and a normal cell line as a control (human normal breast epithelial cells MCF-10A, CRL-10317). All tested compounds showed higher activity against HTB-129 cells than against Caco-2 cells. The ferrocenyl-chloroquine amide conjugates displayed higher activity against both cancer cells than did their parent organic compounds.

SUBSTITUTED QUINOLINE CCR5 RECEPTOR ANTAGONISTS

The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b), enantiomers, diastereomers, salts and solvates thereof wherein R1, R2, R3, R4, R5, and R7 are as defined herein. The invention further includes a method of CCR5-mediated