64307-20-6

Basic information

• Product Name: 4-Pentenenitrile, 3-oxo-5-phenyl-, (E)-
• Synonyms: 4-Pentenenitrile, 3-oxo-5-phenyl-, (E)-
• CAS NO: 64307-20-6
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.19526
• Mol File: 64307-20-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Pentenenitrile, 3-oxo-5-phenyl-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pentenenitrile, 3-oxo-5-phenyl-, (E)-(64307-20-6)
• EPA Substance Registry System: 4-Pentenenitrile, 3-oxo-5-phenyl-, (E)-(64307-20-6)

Safety Data

• Hazardous Substances Data: 64307-20-6(Hazardous Substances Data)

Upstream product

• 103-26-4 Methyl cinnamate 
• 75-05-8 acetonitrile 
• 4192-77-2 ethyl cinnamate 
• 80783-99-9 N-methoxy-N-methylcinnamamide 
• 73400-25-6 {(1E)-3-[(trimethylsilyl)oxy]buta-1,3-dien-1-yl}benzene 

Downstream Products

• 106032-35-3 4-Oxo-1,6-diphenyl-1,4,5,6-tetrahydro-pyridazine-3-carbonitrile 
• 106032-37-5 1-(4-Chloro-phenyl)-4-oxo-6-phenyl-1,4,5,6-tetrahydro-pyridazine-3-carbonitrile 
• 106032-36-4 1-(4-Methoxy-phenyl)-4-oxo-6-phenyl-1,4,5,6-tetrahydro-pyridazine-3-carbonitrile 
• 106032-38-6 1-(4-Nitro-phenyl)-4-oxo-6-phenyl-1,4,5,6-tetrahydro-pyridazine-3-carbonitrile 
• 106032-39-7 2-amino-5,6-dihydro-4,5,6-triphenyl-4H-pyrano<2,3-d>pyridazine-3,8-dicarbonitrile 
• 106032-40-0 ethyl 2-amino-8-cyano-5,6-dihydro-4,5,6-triphenyl-4H-pyrano<2,3-d>pyridazine-3-carboxylate 
• 216390-60-2 N-(2-(2-benzyl-5-methoxybenzofuran-3-yl)ethyl)acetamide 
• 229323-39-1 2-(2-benzyl-5-methoxybenzo[b]furan-3-yl)acetonitrile 
• 738574-39-5 2-(2-benzyl-5-methoxybenzo[b]furan-3-yl)ethylamine 
• 1476782-11-2 (E)-5-styrylfuran-2,3,4-tricarbonitrile 
• 71154-14-8 (E)-3-hydroxy-5-phenylpent-4-enenitrile 
• 106752-25-4 1-Cinnamoyl-2,6-diphenyl-4-oxo-cyclohexan-1,3-dicarbonitril 
• 104919-32-6 Ethyl 2-amino-5-cyano-4-phenyl-6-(2-phenylethyl)-4H-pyran-3-carboxylat 
• 104919-30-4 2-Amino-4-phenyl-6-(2-phenylethenyl)-4H-pyran-3,5-dicarbonitril 

Relevant articles and documents

Synthesis of Functionalized Benzo[b]furans via Oxidative Cyclization of o-Cinnamyl Phenols

Disclosed herein is an efficient synthetic route for the synthesis of functionalized 2-benzyl benzo[b]furans via a regioselective 5-exo-trig intramolecular oxidative cyclization of ortho-cinnamyl phenols using [PdCl2(CH3CN)2] as catalyst and benzoquinone as an oxidant. Further, a sequential ortho-cinnamylation of phenols using cinnamyl alcohols catalyzed by Re2O7, followed by an oxidative cyclization using the above Pd catalyst, is performed. The reaction showed broad substrate scope with good to excellent yields.

Chemoselective efficient synthesis of functionalized β-oxonitriles through cyanomethylation of Weinreb amides

A synthesis of β-oxonitriles is reported via the generation of R1R2CLiCN species followed by the trapping with variously decorated Weinreb amides. The optimization study revealed that lithiation of acetonitriles is best accomplished by deprotonation with MeLi-LiBr at low temperature. The protocol can be conveniently adapted to the synthesis of α-mono or α,α-disubstituted cyanoketones. 15N- and 17O-NMR data are reported for selected compounds. This journal is