643747-86-8

Basic information

• Product Name: 2-(2,6-dichloro-4-nitro-phenylamino)-4-trifluoromethyl-oxazole-5-carboxylic acid ethyl ester
• Synonyms: 2-(2,6-dichloro-4-nitro-phenylamino)-4-trifluoromethyl-oxazole-5-carboxylic acid ethyl ester
• CAS NO: 643747-86-8
• Molecular Weight: 414.125
• Mol File: 643747-86-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2,6-dichloro-4-nitro-phenylamino)-4-trifluoromethyl-oxazole-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-dichloro-4-nitro-phenylamino)-4-trifluoromethyl-oxazole-5-carboxylic acid ethyl ester(643747-86-8)
• EPA Substance Registry System: 2-(2,6-dichloro-4-nitro-phenylamino)-4-trifluoromethyl-oxazole-5-carboxylic acid ethyl ester(643747-86-8)

Safety Data

• Hazardous Substances Data: 643747-86-8(Hazardous Substances Data)

Upstream product

• 20098-48-0 3,4,5-trichloronitrobenzen 
• 135026-17-4 ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate 

Downstream Products

• 724423-47-6 2-(4-amino-2,6-dichloro-phenylamino)-4-trifluoromethyl-oxazole-5-carboxylic acid ethyl ester 

Relevant articles and documents

2-Arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: Synthesis, binding studies and behavioral efficacy

2-Arylamino-4-trifluoromethyl-5-aminomethylthiazoles represent a novel series of high-affinity corticotropin releasing factor-1 receptor (CRF 1R) antagonists that are prepared in three steps in good overall yields. Herein, we report binding SAR as well as anxiolytic activity of an exemplary compound (7a, Ki=8.6 nM) in a mouse canopy model.