64382-92-9Relevant articles and documents
Optimization of the chromone scaffold through QSAR and docking studies: Identification of potent inhibitors of ABCG2
Roussel, Emile,Tran-Nguyen, Viet-Khoa,Bouhedjar, Khalid,Dems, Mohamed Abdesselem,Belaidi, Amine,Matougui, Brahim,Peres, Basile,Azioune, Ammar,Renaudet, Olivier,Falson, Pierre,Boumendjel, Ahcène
, (2019)
The membrane transporter BCRP/ABCG2 has emerged as a privileged biological target for the development of small compounds capable of abolishing multidrug resistance. In this context, the chromone skeleton was found as an excellent scaffold for the design o
Synthetic method 2 and 4 - dibromobenzyl alcohol
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Paragraph 0037-0039, (2021/10/11)
The invention provides 2-4 - dibromobenzyl alcohol synthesis method, and the specific steps are as follows: S1, 2, 4 - dibromotoluene is brominated 2 and 4 - dibromobenzyl bromide in a radical initiator. S2 represents 2, 4 - dibromobenzylacetate in acetat
Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C-H and C-O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans
Zheng, Hong-Xing,Shan, Xiang-Huan,Qu, Jian-Ping,Kang, Yan-Biao
supporting information, p. 3310 - 3313 (2018/06/11)
An intermolecular addition of carbon radicals enabled by a cascade radical coupling strategy is developed. It includes an intermolecular alkyl radical addition to a carbonyl group followed by an intramolecular alkoxy radical addition to haloarenes and produces substituted benzofurans in high yields. The radical nature of this reaction is explored by radical trapping experiments and EPR analysis. The mechanism is investigated by KIE experiments and control experiments. This method could provide rapid and practical access to the key intermediate of TAM-16, a safe and potent antibacterial agent for treating tuberculosis, and, therefore, is of great importance for organic synthesis and the pharmaceutical industry.