64436-13-1

Basic information

• Product Name: ARSENOBETAINE
• Synonyms: (carboxymethyl)trimethylarsoniumhydroxideinnersalt;arsonium,(carboxymethyl)trimethyl-,hydroxide,innersalt;ARSENOBETAINE;ARSENOBETAINE STANDARD;2-(TRIMETHYLARSONIO)ACETATE;Arsonium, (carboxymethyl)trimethyl-, inner salt;Arsenobetaine solution;Arsenobetaine Standard solution
• CAS NO: 64436-13-1
• Molecular Formula: C5H11AsO2
• Molecular Weight: 178.06
• Mol File: 64436-13-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• BRN: 3933180
• CAS DataBase Reference: ARSENOBETAINE(CAS DataBase Reference)
• NIST Chemistry Reference: ARSENOBETAINE(64436-13-1)
• EPA Substance Registry System: ARSENOBETAINE(64436-13-1)

Safety Data

• Hazard Codes: T,N
• Statements: 23/25-50/53
• Safety Statements: 20/21-28-45-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• RTECS: CH9750000
• F: 10-21
• Hazardous Substances Data: 64436-13-1(Hazardous Substances Data)

Usage

Uses

Arsenobetaine has been used to investigate the biochemical response of mice (Mus musculus) to inorganic arsenic exposure using liver as the target organ.

InChI:InChI=1/C5H11AsO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3

Synthetic route

trimethylarsine oxide (4964-14-1) + Iodoacetic acid (64-69-7) → arsenobetaine (64436-13-1)

Conditions	Yield
With GLUTATHIONE at 37℃; for 2h; aq. buffer;	99%
With methylcobalamin; GLUTATHIONE In water at 37℃; for 94h; pH=7.6; Product distribution / selectivity; Tris-HCl buffer solution;

ethoxycarbonylmethyl(trimethyl)arsonium bromide (64436-12-0) → arsenobetaine (64436-13-1)

Conditions	Yield
With ion-exchange resin - form> In water
With Dowex 2 (OH-; water	2.5 g
With Dowex 1 x 8 (OH-)

methylcobalamin + Dimethylarsinic acid (75-60-5) + Iodoacetic acid (64-69-7) → arsenobetaine (64436-13-1) + 2-dimethylarsinyl acetic acid

Conditions	Yield
With GLUTATHIONE In water at 37℃; for 94h; pH=7.6; Product distribution / selectivity; Tris-HCl buffer solution;

Upstream product

• 64436-12-0 ethoxycarbonylmethyl(trimethyl)arsonium bromide 
• 75-60-5 Dimethylarsinic acid 
• 64-69-7 Iodoacetic acid 
• 4964-14-1 trimethylarsine oxide 

Relevant articles and documents

COMPOSITION FOR ALKYLATION, AND METHOD FOR DETOXIFICATION OF TOXIC COMPOUND USING THE COMPOSITION

It is an object of the present invention to provide a beneficial composition in order to detoxify the harmful compound containing arsenic etc. effectively and systematically and a method for detoxifying a harmful compound by using the composition. The composition for the alkylation according to the present invention is characterized in that the composition contains a cobalt complex. The method of detoxifying the harmful compound according to the present invention is characterized in that a harmful compound containing at least one element selected from the groups comprising arsenic, antimony and selenium is detoxified by the alkylation of the harmful compound, in the presence of the composition according to the present invention.

Synthesis of trimethylated phosphonium and arsonium analogues of the osmoprotectant glycine betaine; contrasted biological activities in two bacterial species

Phosphoniobetaine and arsenobetaine, the P and As analogues of glycine betaine (trimethylammonioacetate) were synthesized and assayed for activity in bacterial osmoprotection biotests, using Escherichia coli and Rhizobium meliloti as model organisms. The P- and As-betaines displayed similar osmoprotective activities in E. coli, but were highly toxic in the betaine- demethylating bacterium R. meliloti.