64505-07-3

Basic information

• Product Name: Acetamide, N-(1-methylene-2-oxopropyl)- (9CI)
• Synonyms: Acetamide, N-(1-methylene-2-oxopropyl)- (9CI)
• CAS NO: 64505-07-3
• Molecular Formula: C₆H₉NO₂
• Molecular Weight: 127.14116
• Product Categories: ACETYLGROUP
• Mol File: 64505-07-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetamide, N-(1-methylene-2-oxopropyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(1-methylene-2-oxopropyl)- (9CI)(64505-07-3)
• EPA Substance Registry System: Acetamide, N-(1-methylene-2-oxopropyl)- (9CI)(64505-07-3)

Safety Data

• Hazardous Substances Data: 64505-07-3(Hazardous Substances Data)

Upstream product

• 98022-59-4 3-azido-butan-2-one 
• 108-24-7 acetic anhydride 
• 60-35-5 acetamide 
• 431-03-8 dimethylglyoxal 
• 144522-62-3 N-(2-Ethyl-4-oxo-4H-quinazolin-3-yl)-N-((Z)-2-hydroxy-1-methyl-propenyl)-acetamide 
• 17292-61-4 2,3-butanedione mono-(O-acetyl oxime) 

Downstream Products

• 6628-81-5 2-acetamido-3-butanone 
• 142924-42-3 N-(3-oxobutan-2-yl)acetamide 
• 4293-60-1 3-(acetylamino)-butan-2-ol 

Relevant articles and documents

Iron-catalysed 1,2-acyl migration of tertiary α-azido ketones and 2-azido-1,3-dicarbonyl compounds

Iron-catalysed 1,2-acyl migration of tertiary α-azido ketones and 2-azido-1,3-dicarbonyl compounds provides a simple and atom-economical approach toward enamides and isoquinolones. This paper reports two catalyst systems for these transformations which employ iron(ii) complexes [Fe(dpbz)]Br2 (dpbz = 1,2-bis(diphenylphosphino)benzene) and FeBr2/Et3N, respectively. [Fe(dpbz)]Br2 was found to be highly effective at converting 2-azido-2,3-dihydro-1H-inden-1-ones to isoquinolones. The reagent combination of FeBr2/Et3N, on the other hand, exhibited a broader catalytic scope, owing to the beneficial effect of Et3N. This latter catalyst system enables 2-azido-2-methyl-1,3-dicarbonyl compounds to be converted to the corresponding enamides under mild conditions in good yields.

Asymmetric transfer hydrogenation of α,β-unsaturated, α-tosyloxy and α-substituted ketones

Asymmetric transfer hydrogenation of cyclic and acyclic α,β-unsaturated ketones catalysed by η6-p-cymene/ ruthenium(II) and η5-pentamethylcyclopentadienyl/rhodium(III) complexes have been investigated. Cyclic α,β-unsaturated ketones appeared to be more suitable substrates for the synthesis of enantiomerically pure allylic alcohols than do acyclic α,β-unsaturated ketones. A proposed mechanism for the formation of 4-phenyl-[1,3]-dioxolan-2-one from α-tosyloxy- and halo-substituted acetophenones is discussed. The results of further investigations into the reduction of a range of α- tosyloxyacetophenones and the dynamic kinetic resolution of α-substituted ketones is presented.

Decomposition of 2-Azido Ketones to 2-(Acetylamino)-2-alken-1-ones by Perrhenate Catalysis

The thermally induced elimination of nitrogen from cyclic and acyclic 2-azido ketones 2 is accelerated by catalytic amounts of perrhenate.In acetic anhydride - if necessary in the presence of small amounts of a mineral acid - 2-(acetylamino)-2-alken-1-ones 3 are formed in good yields.The decomposition rates of the catalysed and the uncatalysed thermolysis are compared.