64544-71-4

Basic information

• Product Name: 1-ethyl-1,3-diphenylurea
• Synonyms: 1-ethyl-1,3-diphenylurea
• CAS NO: 64544-71-4
• Molecular Formula: C₁₅H₁₆N₂O
• Molecular Weight: 240.30034
• EINECS: 264-940-5
• Mol File: 64544-71-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 423.3°C at 760 mmHg
• Flash Point: 209.8°C
• Appearance: /
• Density: 1.172g/cm³
• Vapor Pressure: 2.26E-07mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 1-ethyl-1,3-diphenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethyl-1,3-diphenylurea(64544-71-4)
• EPA Substance Registry System: 1-ethyl-1,3-diphenylurea(64544-71-4)

Safety Data

• Hazardous Substances Data: 64544-71-4(Hazardous Substances Data)

Usage

General Description

1-ethyl-1,3-diphenylurea, also known as Etorphine, is a synthetic opioid that is structurally related to morphine. It is an extremely potent analgesic, with effects 1,000 to 3,000 times stronger than morphine. Due to its high potency, etorphine is not approved for human use, but is mainly used in veterinary medicine as a tranquilizer or anesthetic for large animals such as elephants, rhinos, and large cats. Etorphine has a high potential for abuse and is classified as a Schedule I controlled substance in the United States. It is also classified as a dangerous drug in most other countries. Etorphine is considered to be one of the most powerful opioids and should only be used by trained professionals in a controlled environment.

InChI:InChI=1/C15H16N2O/c1-2-17(14-11-7-4-8-12-14)15(18)16-13-9-5-3-6-10-13/h3-12H,2H2,1H3,(H,16,18)

Upstream product

• 103-69-5 N-ethyl-N-phenylamine 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 103-70-8 Formanilid 
• 97-94-9 triethyl borane 
• 103-71-9 phenyl isocyanate 
• 91-66-7 N,N-diethylaniline 
• 15093-51-3 N,N'-diphenyl-N-ethylthiourea 
• 33758-39-3 N-ethyl-N-phenyl carbamoyl chloride 
• 62-53-3 aniline 
• 64-67-5 diethyl sulfate 
• 603-54-3 N,N-diphenylurea 

Downstream Products

• 103-71-9 phenyl isocyanate 
• 103-69-5 N-ethyl-N-phenylamine 
• 101092-87-9 1-ethyl-1,3-bis(4-nitrophenyl)urea 

Relevant articles and documents

2,2,2-Trifluroenthanol promoted synthesis of unsymmetrical ureas from dioxazolones and amines via tandem lossen rearrangement/condensation process

A 2,2,2-trifluroenthanol (TFE) promoted synthesis of unsymmetric ureas was described. This approach enabled the construction of a variety of ureas from the readily prepared and easy-to-handle dioxazolones and amines via tandem Lossen rearrangement/condensation process. The reaction featured mild conditions for the urea synthesis under metal-free conditions, which was successively applied in the scale-up synthesis of herbicides Monuro and Isoproturon.

Synthesis of unsymmetrical phenylurea derivatives via oxidative cross coupling of aryl formamides with amines under metal-free conditions

A new synthetic approach for phenylurea derivatives involving the cross coupling of N-aryl formamides with amines through the formation of isocyanate intermediates in the presence of hypervalent iodine reagents is described.

Molecular Scaffolds I: Intramolecular Hydrogen Bonding in a Family of Di- and Triureas

Di- and triurea derivatives 1 can be prepared by an iterative procedure and are found to exist in intramolecularly hydrogen bonded 10-membered ring conformations, in which substituents R1 and R2 and hydrogen bonding control the direction of the urea carbonyl groups.