6455-31-8

Basic information

• Product Name: 3-Isoxazolamine,5-phenyl-(9CI)
• Synonyms: 3-Isoxazolamine,5-phenyl-(9CI);5-PHENYL-1,2-OXAZOL-3-AMINE
• CAS NO: 6455-31-8
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17262
• Product Categories: OXAZOLE
• Mol File: 6455-31-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 139-139.5 °C
• Boiling Point: 379.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.204±0.06 g/cm3(Predicted)
• PKA: 2.02±0.10(Predicted)
• CAS DataBase Reference: 3-Isoxazolamine,5-phenyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isoxazolamine,5-phenyl-(9CI)(6455-31-8)
• EPA Substance Registry System: 3-Isoxazolamine,5-phenyl-(9CI)(6455-31-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 6455-31-8(Hazardous Substances Data)

Usage

General Description

3-Isoxazolamine, 5-phenyl (9CI) is a chemical compound with the molecular formula C9H8N2O. It belongs to the isoxazole class of organic compounds, which are heterocyclic aromatic compounds containing a five-membered ring with three carbon atoms, one oxygen atom, and one nitrogen atom. This specific compound is characterized by the presence of a phenyl group, which is a six-carbon aromatic ring attached to the isoxazolamine structure. The exact properties and uses of 3-Isoxazolamine, 5-phenyl (9CI) are not readily available, but isoxazole derivatives are known to have potential pharmacological activities, such as anti-inflammatory, analgesic, and antimicrobial properties, making them of interest for various pharmaceutical and medical applications. Further research and experimentation are necessary to determine the specific characteristics and potential uses of this compound.

Upstream product

• 91132-63-7 Benzoylketen-O-aethyl-O,N-acetal 
• 78583-84-3 3-chloro-3-phenylprop-2-enenitrile 
• 33603-87-1 β-chlorocinnamaldehyde 
• 1311369-43-3 N-hydroxy-2-(2-phenyl-1,3-dioxolan-2-yl)ethanimidamide 
• 5738-30-7 (2-phenyl-[1,3]dioxolan-2-yl)-acetonitrile 
• 614-16-4 Benzoylacetonitrile 
• 935-02-4 3-Phenyl-2-propynonitrile 
• 6738-06-3 phenylethynylmagnesium bromide 
• 66181-90-6 3-chloro-2-methyl-5-phenylisoxazolium chloride 
• 141-52-6 sodium ethanolate 
• 71854-39-2 N-(5-phenyl-3-isoxazolyl)phthalimide 
• 14443-97-1 β-bromocinnamonitrile 
• 90557-55-4 N-hydroxy-3-oxo-3-phenyl-propionamidine 
• 19521-13-2 α,β-dibromo-β-phenylpropionitrile 

Downstream Products

• 13273-64-8 3-benzoylamido-5-phenyl-isoxazole 
• 132576-16-0 3-(4-Dimethylaminophenylazo)-5-phenylisoxazole 
• 1188908-36-2 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-phenylisoxazol-3-yl)urea 
• 1188908-38-4 phenyl (5-phenylisoxazol-3-yl)carbamate 

Relevant articles and documents

Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors

Two series comprising 20 novel benzenesulfonamides bearing thioureido-linked pyrazole 8 and amino-1,2,4-thiadiazole 10 were synthesized and assayed as human carbonic anhydrase (hCA) inhibitors against isoforms I and II as well as the tumor-associated isof

SUBSTITUTED FURO[3,2-D]PYRIMIDINES AND USES THEREOF

The present disclosure provides compounds that are inhibitors of PIKfyve and/or PI3 kinases, and are therefore useful for the treatment of neurological diseases treatable by inhibition of PIKfyve and/or PI3 kinases. Also provided are pharmaceutical compositions containing such compounds, and methods of treatment of neurological diseases using such compounds.

Structure-activity relationship study of E6 as a novel necroptosis inducer

Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations.