64559-97-3Relevant articles and documents
Enantioselective benzylation and allylation of α-trifluoromethoxy indanones under phase-transfer catalysis
Liang, Yumeng,Maeno, Mayaka,Zhao, Zhengyu,Shibata, Norio
, (2019)
The organo-catalyzed enantioselective benzylation reaction of α-trifluoromethoxy indanones afforded α-benzyl-α-trifluoromethoxy indanones with a tetrasubstituted stereogenic carbon center in excellent yield with moderate enantioselectivity (up to 57% ee). Cinchona alkaloid-based chiral phase transfer catalysts were found to be effective for this transformation, and both enantiomers of α-benzyl-α-trifluoromethoxy indanones were accessed, depended on the use of cinchonidine and cinchonine-derived catalyst. The method was extended to the enantioselective allylation reaction of α-trifluoromethoxy indanones to give the allylation products in moderate yield with good enantioselectivity (up to 76% ee).
Catalytic Enantioselective Transannular Morita-Baylis-Hillman Reaction
Mato, Raquel,Manzano, Rubén,Reyes, Efraim,Carrillo, Luisa,Uria, Uxue,Vicario, Jose L.
supporting information, p. 9495 - 9499 (2019/06/17)
Catalytic and enantioselective approaches to transannular reactions are very limited and mostly are based on chiral Lewis acid catalyzed pericyclic reactions. In this report, we present an efficient and straightforward methodology to access bicyclic carbo
Divergent synthesis of N-heterocycles by Pd-catalyzed controllable cyclization of vinylethylene carbonates
Yang, Yuwen,Yang, Weibo
supporting information, p. 12182 - 12185 (2018/11/21)
Here, we report a palladium-catalyzed controllable cyclization of vinyl ethylene carbonates that proceeds through formal migration [2+3] and [5+2] cycloadditions, respectively, under mild conditions. The transformation described here affords a series of synthetically versatile 5,7-membered N-heterocycles which are found in natural products and pharmaceuticals with biological and medicinal properties.