64598-39-6

Basic information

• Product Name: Methanone, (4-chlorophenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-
• CAS NO: 64598-39-6
• Molecular Formula: C17H13ClN2O2
• Molecular Weight: 312.755
• Mol File: 64598-39-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Methanone, (4-chlorophenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-chlorophenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-(64598-39-6)
• EPA Substance Registry System: Methanone, (4-chlorophenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-(64598-39-6)

Safety Data

• Hazardous Substances Data: 64598-39-6(Hazardous Substances Data)

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 100-63-0 phenylhydrazine 
• 89-25-8 edaravone 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 133176-03-1 (5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)(4-chlorophenyl)methanone 
• 1078132-20-3 C₂₄H₁₉ClN₂O₂ 
• 1078132-21-4 C₂₄H₁₈ClN₃O₄ 
• 1078132-19-0 C₂₄H₁₈ClFN₂O₂ 

Relevant articles and documents

Pyrazole and Triazole Derivatives as Mycobacterium tuberculosis UDP-Galactopyranose Inhibitors

UDP-galactopyranose mutase (UGM) is an essential enzyme involved in the bacterial cell wall synthesis, and is not present in mammalian cells. Thus, UGM from Mycobacterium tuberculosis (Mtb) represents a novel and attractive drug target for developing antituberculosis agents. A pyrazole-based compound, MS208, was previously identified as a mixed inhibitor of MtbUGM which targets an allosteric site. To understand more about the structure activity relationship around the MS208 scaffold as a MtbUGM inhibitor, thirteen pyrazoles and triazole analogues were synthesized and tested against both MtbUGM and Mycobacterium tuberculosis in vitro. While the introduced structural modifications to MS208 did not improve the antituberculosis activity, most of the compounds showed MtbUGM inhibitory activity. Interestingly, the pyrazole derivative DA10 showed a competitive model for MtbUGM inhibition with improved Ki value of 51 ± 4 μM. However, the same compound did not inhibit the growth of Mycobacterium tuberculosis.

Synthesis, Structure, and Biological Activities of [5-(Arylthio/sulfinyl/sulfonyl)-3-methyl-1-phenyl-1 H -pyrazol-4-yl]-arylmethanones

A series of novel N-phenylpyrazolyl aryl methanones derivatives containing the arylthio/sulfinyl/sulfonyl group have been synthesized via multi-step reactions from 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one and characterized by melting point, 1H NM