64622-45-3

Basic information

• Product Name: 2-pyridylmethyl 2-(4-isobutylphenyl)propionate
• Synonyms: 2-pyridylmethyl 2-(4-isobutylphenyl)propionate;Ibuprofenpiconol;BE 100;Pimeprofen;Staderm;U 75630;Vesicum;2-(p-Isobutylphenyl)propionic acid 2-pyridylmethyl ester
• CAS NO: 64622-45-3
• Molecular Formula: C19H23NO2
• Molecular Weight: 297.39
• EINECS: 264-979-8
• Mol File: 64622-45-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 438.9°C (rough estimate)
• Appearance: /
• Density: 1.0971 (rough estimate)
• Refractive Index: 1.5000 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Acetone (Slightly), Chloroform (Slightly), Methanol (Sparingly)
• PKA: 3.36±0.12(Predicted)
• CAS DataBase Reference: 2-pyridylmethyl 2-(4-isobutylphenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-pyridylmethyl 2-(4-isobutylphenyl)propionate(64622-45-3)
• EPA Substance Registry System: 2-pyridylmethyl 2-(4-isobutylphenyl)propionate(64622-45-3)

Safety Data

• Hazardous Substances Data: 64622-45-3(Hazardous Substances Data)

Usage

Description

Pimaprofen (ibuprofen piconol) is an antiinflammatory agent useful in the topical treatment of acute and chronic eczema, and contact and atopic dermatitis.

Originator

Hisamitsu (Japan)

Uses

Ibuprofen Piconol is an anti-inflammatory agent that can be synthesized from Ibuprofen (I140000), which is a selective cyclooxygenase inhibitor.

Brand name

BESICUM; STADERM

InChI:InChI=1/C19H23NO2/c1-14(2)12-16-7-9-17(10-8-16)15(3)19(21)22-13-18-6-4-5-11-20-18/h4-11,14-15H,12-13H2,1-3H3

Upstream product

• 586-98-1 2-Hydroxymethylpyridine 
• 61566-34-5 (+/-)-ibuprofen methyl ester 
• 71381-91-4 (+/-)-2-(4-isobutylphenyl)propanoyl chloride 
• 15687-27-1 ibuprofen 
• 2387-23-7 1,3-Dicyclohexylurea 

Relevant articles and documents

METHOD FOR PRODUCING ESTER GROUP-CONTAINING COMPOUND

The present invention provides a novel method for producing an ester group-containing compound and a derivative produced using the compound as a synthetic intermediate. The invention also provides a polymerizable composition containing the compound obtained by the production method and a film-shaped polymer obtained by polymerizing the polymerizable composition. The present invention is a method for producing an ester group-containing compound, the method including a mixing step of mixing a condensing agent, a Bronsted acid, a carboxylic acid, and a phenol or an alcohol to prepare a reaction mixture. The Bronsted acid selected is other than the condensing agent, the carboxylic acid, and the phenol.

ZINC COMPLEX

A zinc complex characterized in exhibiting an octahedral structure and being configured from repeating units represented by general formula (I): wherein L represents a linker region, and R1 represents a C1-4 alkyl group, which can have a halogen atom.

A green chemistry approach to ibuprofen piconol

Ibuprofen piconol synthesis has been described. The use of solid catalyst has demonstrated green chemistry approach with promoted atom economy of 94% compared to the reported 68%.