64700-71-6

Basic information

• Product Name: 2,3-dinor-6-ketoprostaglandin F1alpha
• Synonyms: 2,3-Dinor-6-keto-pgf1alpha;2,3-Dinor-6-oxo-pgf1alpha;2,3-Dinor-6-oxoprostaglandin F1alpha;2,3-Dkpgf1alpha;Cyclopentanepentanoic acid, 3,5-dihydroxy-2-((1E,3S)-3-hydroxy-1-octenyl)-gamma-oxo-, (1R,2R,3R,5S)-;Cyclopentanepentanoic acid, 3,5-dihydroxy-2-(3-hydroxy-1-octenyl)-gamma-oxo-, (1R-(1alpha,2beta(1E,3S*),3alpha,5alpha))-;Pgi2-m
• CAS NO: 64700-71-6
• Molecular Formula: C18H30O6
• Molecular Weight: 342.429
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 64700-71-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 538.7 °C at 760 mmHg
• Flash Point: 293.7 °C
• Appearance: /
• Density: 1.232 g/cm³
• Vapor Pressure: 7.5E-14mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 2,3-dinor-6-ketoprostaglandin F1alpha(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dinor-6-ketoprostaglandin F1alpha(64700-71-6)
• EPA Substance Registry System: 2,3-dinor-6-ketoprostaglandin F1alpha(64700-71-6)

Safety Data

• Hazardous Substances Data: 64700-71-6(Hazardous Substances Data)

Usage

Description

2,3-dinor-6-ketoprostaglandin F1alpha, also known as a metabolite of Prostaglandin, is a prostanoid derived from prostaglandin F1alpha. It is characterized by the absence of two methylenes in the carboxyalkyl chain and the presence of an oxo group at the 6-position. This bioactive molecule plays a significant role in various physiological processes and has potential applications in different industries.

Uses

Used in Pharmaceutical Industry:
2,3-dinor-6-ketoprostaglandin F1alpha is used as a therapeutic agent for its potential role in modulating physiological processes. As a metabolite of Prostaglandin, it may have implications in treating conditions related to inflammation, blood flow regulation, and other prostaglandin-mediated functions.
Used in Research and Development:
In the field of research and development, 2,3-dinor-6-ketoprostaglandin F1alpha serves as an important compound for studying the structure, function, and mechanisms of action of prostaglandins. This knowledge can be applied to develop new drugs and therapies targeting prostaglandin-related pathways.
Used in Diagnostic Applications:
2,3-dinor-6-ketoprostaglandin F1alpha can be utilized as a biomarker in diagnostic tests to assess the levels of prostaglandins in the body. This can help in the early detection and monitoring of conditions related to prostaglandin imbalances, such as certain types of cancer, cardiovascular diseases, and inflammatory disorders.

InChI:InChI=1/C18H30O6/c1-2-3-4-5-12(19)6-8-14-15(17(22)11-16(14)21)10-13(20)7-9-18(23)24/h6,8,12,14-17,19,21-22H,2-5,7,9-11H2,1H3,(H,23,24)/b8-6+/t12-,14+,15+,16+,17-/m0/s1

Upstream product

• 92640-89-6 4-[(3aS,4R,5R,6aS)-5-Hydroxy-4-((E)-(S)-3-hydroxy-oct-1-enyl)-2-oxo-hexahydro-cyclopenta[b]furan-3-yl]-4-oxo-butyric acid methyl ester 
• 61628-05-5 (3aR,4R,5R,6aS)-hexahydro-5-tert-butyldimethylsilyloxy-4-[(1E,3S)-3-tert-butyldimethylsilyloxy-(1E)-octenyl]-2H-cyclopenta[β]furan-2-one 
• 82290-18-4 (1S,2R,3R,4R)-2-((Z)-5-Hydroxy-pent-2-enyl)-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanol 
• 82290-21-9 Acetic acid (1S,2R,3R,4R)-2-[5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-pentyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentyl ester 
• 82290-23-1 (1S,2R,3R,4R)-2-[(Z)-5-(tert-Butyl-dimethyl-silanyloxy)-pent-2-enyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanol 
• 82290-24-2 5-(tert-Butyl-dimethyl-silanyloxy)-1-{(1R,2R,3R,5S)-5-hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentyl}-pentan-2-one 
• 82290-25-3 5-[(1R,2R,3R,5S)-5-Acetoxy-3-hydroxy-2-((E)-(S)-3-hydroxy-oct-1-enyl)-cyclopentyl]-4-oxo-pentanoic acid 
• 82290-26-4 2,3-dinor-6-oxo-PGF₁α 6,9-hemiacetal 1,6-lactone 
• 37786-09-7 11,15-bis(tetrahydro-2H-pyran-2-yl)-prostaglandin F_2α 

Relevant articles and documents

A NOVEL SYNTHESIS OF 2,3-DINOR-6-OXO-PROSTAGLANDIN F1α

The synthesis of 2,3-dinor-6-oxoprostaglandin F1α, the major metabolite of prostacyclin, from the prostaglandin lactone intermediate (2) is reported.