64743-26-6

Basic information

• Product Name: Silane, 2,4-cyclopentadien-1-yldimethylphenyl-
• CAS NO: 64743-26-6
• Molecular Formula: C13H16Si
• Molecular Weight: 200.356
• Mol File: 64743-26-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Silane, 2,4-cyclopentadien-1-yldimethylphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, 2,4-cyclopentadien-1-yldimethylphenyl-(64743-26-6)
• EPA Substance Registry System: Silane, 2,4-cyclopentadien-1-yldimethylphenyl-(64743-26-6)

Safety Data

• Hazardous Substances Data: 64743-26-6(Hazardous Substances Data)

Upstream product

• 542-92-7 cyclopenta-1,3-diene 
• 768-33-2 phenyldimethylsilyl chloride 
• 108-86-1 bromobenzene 

Downstream Products

• 62251-98-3 (+)-coronafacic acid 
• 1373390-80-7 C₂₁H₂₆O₃Si 
• 1373390-81-8 C₁₉H₂₂OSi 
• 1384264-04-3 bis-[((phenyl)dimethylsilane)cyclopentadienyl]titanium(IV) dichloride 
• 890833-72-4 [Cp(CpSiMe₂Ph)ZrCl₂] 
• 361482-63-5 (1R,2R,3S)-2-(Dimethyl-phenyl-silanyl)-cyclopent-4-ene-1,3-diol 

Relevant articles and documents

Synthesis and cytotoxicity studies of silyl-substituted titanocene dichloride derivatives

Six new titanocene compounds have been isolated and characterized. These compounds were synthesized from their silyl-substituted fulvene or cyclopentadiene precursors using Super Hydride (LiBEt3H) or n-BuLi, followed by transmetalation with titanium tetrachloride, to yield the corresponding titanocene dichloride derivatives. These complexes are bis-[((phenyl)dimethylsilane)cyclopentadienyl] titanium(IV) dichloride (3a), bis-[((4-methoxyphenyl)dimethylsilane)cyclopentadienyl] titanium(IV) dichloride (3b), bis-[((4-N,N-dimethylmethanamine)dimethylsilane)cyclopentadienyl] titanium(IV) dichloride (3c), bis-[((4-N,N-diethylmethanamine)dimethylsilane) cyclopentadienyl] titanium(IV) dichloride (3d), bis-[((1-methyl-5- trimethylsilyl)indol-3-yl)methylcyclopentadienyl] titanium(IV) dichloride (4e), and bis-[((1-methyl-3-diethylaminomethyl-5-trimethylsilyl)indol-2-yl) methylcyclopentadienyl] titanium(IV) dichloride (4f). The two titanocenes 3a and 3b were crystallized and characterized by X-ray crystallography, while all six titanocenes were tested for their cytotoxicity through MTT-based in vitro tests on CAKI-1 cell lines in order to determine their IC50 values. Titanocenes were found to have IC50 values of 139 (±5), 106 (± 4), 127 (±4), 104 (±9), 90 (±6), and 15 (±2) μM.

ALKYLENE BRIDGED SULTAM COMPOUNDS USEFUL AS MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION

Disclosed are sultam compounds of Formula (I) or a pharmaceutically-acceptable salt thereof. Also disclosed are methods of using such compounds in the treatment of at least one nuclear hormone receptor-associated condition, such as, for example, cancer and immune disorders, and at least one pharmaceutical composition comprising such compounds.

Convenient route to both enantiomerically pure forms of trans-4,5-dihydroxy-2-cyclopenten-1-one: Efficient synthesis of the neocarzinostatin chromophore core

An enantioselective synthesis of an epoxybicyclo[7.3.0]dodecenediyne core system of the neocarzinostatin chromophore has been achieved via intramolecular acetylide addition and palladium-mediated coupling of iodocyclopentene 5 with alkyne 6. The key cyclopentene moiety, trans-4,5-dihydroxy-2-cyclopenten-1-one 7, was conveniently prepared in both enantiomerically pure forms via enzymatic desymmetrization of meso-3,4,5-trans,trans-trihydroxycyclopentene derivatives.