6477-52-7 Usage
Description
Coenzyme A-glutathione mixed disulfide is an organic disulfide that is formed through the oxidative coupling of the thiol functions of coenzyme A and glutathione.
Uses
Used in Pharmaceutical Industry:
Coenzyme A-glutathione mixed disulfide is used as a pharmaceutical agent for its potential role in the regulation of cellular redox balance and detoxification processes. It may have applications in the treatment of various diseases and conditions related to oxidative stress and cellular dysfunction.
Used in Research Applications:
Coenzyme A-glutathione mixed disulfide is used as a research tool for studying the mechanisms of oxidative stress, redox signaling, and the role of coenzyme A and glutathione in cellular metabolism and homeostasis. It can help researchers gain insights into the molecular pathways and targets for developing therapeutic interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 6477-52-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,7 and 7 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6477-52:
(6*6)+(5*4)+(4*7)+(3*7)+(2*5)+(1*2)=117
117 % 10 = 7
So 6477-52-7 is a valid CAS Registry Number.
InChI:InChI=1/C31H51N10O22P3S2/c1-31(2,12-42)24(27(48)36-6-5-18(43)35-7-8-67-68-11-16(33)28(49)40(9-20(45)46)19(44)4-3-15(32)30(50)51)62-66(57,58)63-65(55,56)59-10-17-23(61-64(52,53)54)22(47)29(60-17)41-14-39-21-25(34)37-13-38-26(21)41/h13-17,22-24,29,42,47H,3-12,32-33H2,1-2H3,(H,35,43)(H,36,48)(H,45,46)(H,50,51)(H,55,56)(H,57,58)(H2,34,37,38)(H2,52,53,54)/t15-,16-,17+,22+,23+,24?,29+/m0/s1
6477-52-7Relevant articles and documents
Kinetics and Equilibria of Thiol/Disulfide Interchange Reactions of Selected Biological Thiols and Related Molecules with Oxidized Glutathione
Keire, David A.,Strauss, Erin,Guo, Wei,Noszal, Bela,Rabenstein, Dallas L.
, p. 123 - 127 (2007/10/02)
Rate constants for reaction of coenzyme A and cysteine with oxidized glutathione (GSSG) and equilibrium constants for the reaction of coenzyme A, cysteine, homocysteine, cysteamine, and related thiols with GSSG by thiol/disulfide interchange were determined over a range of pD values by NMR spectroscopy.The rate constants for reaction of the thiolate anion forms of coenzyme A and cysteine with GSSG suggest that reduction of GSSG by coenzyme A and cysteine is a mechanistically uncomplicated SN2 reaction.Equilibrium constants for the thiol/disulfide interchange reactions show a strong dependence on the Bronsted basicity of the thiolate anion.In a similar way, ΔE0', the difference between the half-cell potentials for the RSSR/RSH and GSSG/GSH redox couples, is linearly dependent on the difference between the pKA values of RSH and glutathione: ΔE0' = 64ΔpKA - 7.7 where ΔE0' is in units of mV.The reducing strength at a given pH is also determined by the fraction of the thiol present in the reactive thiolate form.At pD 7, the half-cell potentials for coenzyme A, cysteine, homocysteine, and cysteamine are close to that of glutathione, the major intracellular thiol redox system, which suggests that small changes in the intracellular redox potential can cause significant changes in the intracellular distribution of these biological thiols between their reduced and oxidized forms.