64778-74-1

Basic information

• Product Name: (R)-(-)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane
• CAS NO: 64778-74-1
• Molecular Weight: 240.259
• Mol File: 64778-74-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-(-)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane(64778-74-1)
• EPA Substance Registry System: (R)-(-)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane(64778-74-1)

Safety Data

• Hazardous Substances Data: 64778-74-1(Hazardous Substances Data)

Upstream product

• 16094-57-8 (-)-DMA hydrochloride 

Relevant articles and documents

Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane

The serotonin (5-HT) receptor affinities and behavioral (discriminative stimulus) properties of a series of 4-substituted derivatives of 1-(2,5-dimethoxyphenyl)-2-aminopropanes (2,5-DMA) were investigated. The substituents at the 4-position included H, OMe, OEt, Me, Et, F, Br, I, and NO2. Substituent lipophilicities (π values) of these functionalities appear to have a minimal effect on either 5-HT receptor affinity or behavioral activity. Those derivatives previously found to be most potent in human studies possess significant affinity for 5-HT receptors. Furthermore, when rats trained to discriminate (±)-1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline were used, generalization was found to occur upon administration of the 4-substituted 2,5-DMA derivatives. Because a direct relationship exists between the ED50 values obtained from these discrimination studies and human hallucinogenic potencies, the discriminative stimulus paradigm, with DOM as a training drug, appears to be a useful tool for comparing the quantitative and qualitative (DOM-like) effects produced by certain hallucinogenic agents.