6478-73-5 Usage
Description
5,6-DICHLOROBENZIMIDAZOLE is a benzimidazole derivative characterized by the presence of two chlorine atoms at the 5th and 6th positions on the benzene ring. It exhibits potent inhibitory activity against milk xanthine oxidase, a key enzyme involved in the metabolism of purines and the production of uric acid.
Uses
Used in Pharmaceutical Industry:
5,6-DICHLOROBENZIMIDAZOLE is used as a potent inhibitor of milk xanthine oxidase for the development of therapeutic agents targeting hyperuricemia and gout. Its inhibitory activity helps in reducing the levels of uric acid in the body, providing relief from the symptoms and complications associated with these conditions.
Used in Research Applications:
5,6-DICHLOROBENZIMIDAZOLE is also utilized in research settings as a tool compound to study the role of xanthine oxidase in various biological processes and diseases. Its inhibitory properties allow researchers to investigate the effects of modulating xanthine oxidase activity on cellular functions and disease progression.
Check Digit Verification of cas no
The CAS Registry Mumber 6478-73-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,7 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6478-73:
(6*6)+(5*4)+(4*7)+(3*8)+(2*7)+(1*3)=125
125 % 10 = 5
So 6478-73-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H4Cl2N2/c8-4-1-6-7(2-5(4)9)11-3-10-6/h1-3H,(H,10,11)
6478-73-5Relevant articles and documents
One-Pot Transformation of Lignin and Lignin Model Compounds into Benzimidazoles
Guo, Tao,He, Jianghua,Liu, Tianwei,Zhang, Yuetao
supporting information, (2022/02/07)
It is a challenging task to simultaneously achieve selective depolymerization and valorization of lignin due to their complex structure and relatively stable bonds. We herein report an efficient depolymerization strategy that employs 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as oxidant/catalyst to selectively convert different oxidized lignin models to a wide variety of 2-phenylbenzimidazole-based compounds in up to 94 % yields, by reacting with o-phenylenediamines with varied substituents. This method could take full advantage of both Cβ and/or Cγ atom in lignin structure to furnish the desirable products instead of forming byproducts, thus exhibiting high atom economy. Furthermore, this strategy can effectively transform both the oxidized hardwood (birch) and softwood (pine) lignin into the corresponding degradation products in up to 45 wt% and 30 wt%, respectively. Through a “one-pot” process, we have successfully realized the oxidation/depolymerization/valorization of natural birch lignin at the same time and produced the benzimidazole derivatives in up to 67 wt% total yields.
