647858-19-3

Basic information

• Product Name: Ethanol, 2-(2-fluoro-4-nitrophenoxy)-
• CAS NO: 647858-19-3
• Molecular Formula: C8H8FNO4
• Molecular Weight: 201.154
• Mol File: 647858-19-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-(2-fluoro-4-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-(2-fluoro-4-nitrophenoxy)-(647858-19-3)
• EPA Substance Registry System: Ethanol, 2-(2-fluoro-4-nitrophenoxy)-(647858-19-3)

Safety Data

• Hazardous Substances Data: 647858-19-3(Hazardous Substances Data)

Upstream product

• 350-31-2 1-chloro-2-fluoro-4-nitrobenzene 
• 107-21-1 ethylene glycol 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 647858-37-5 methanesulfonic acid 2-(2-fluoro-4-nitro-phenoxy)-ethyl ester 
• 647858-27-3 N-{3-[4-(2-benzyloxy-ethoxy)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 647858-46-6 (R)-5-Azidomethyl-3-[3-fluoro-4-(2-piperidin-1-yl-ethoxy)-phenyl]-oxazolidin-2-one 
• 647858-45-5 (R)-5-Azidomethyl-3-[3-fluoro-4-(2-thiomorpholin-4-yl-ethoxy)-phenyl]-oxazolidin-2-one 
• 647858-44-4 (R)-5-Azidomethyl-3-[3-fluoro-4-(2-morpholin-4-yl-ethoxy)-phenyl]-oxazolidin-2-one 
• 647858-48-8 (S)-5-Aminomethyl-3-[3-fluoro-4-(2-thiomorpholin-4-yl-ethoxy)-phenyl]-oxazolidin-2-one 
• 647858-49-9 (S)-5-Aminomethyl-3-[3-fluoro-4-(2-piperidin-1-yl-ethoxy)-phenyl]-oxazolidin-2-one 
• 647858-47-7 (S)-5-Aminomethyl-3-[3-fluoro-4-(2-morpholin-4-yl-ethoxy)-phenyl]-oxazolidin-2-one 

Relevant articles and documents

Design, synthesis, and biological evaluation of some novel 4-aminoquinazolines as Pan-PI3K inhibitors

A series of 4-aminoquinazolines derivatives containing hydrophilic group were designed and identified as potent Pan-PI3K inhibitors in this study. The results of antiproliferative assays in vitro showed that this series of compounds had strong inhibition of tumor growth, especially compound 7b for MCF-7 cells but weak inhibition to normal cells. PI3K kinase assay showed that 7b had high activity for three PI3K isoforms with the IC50 values of picomole. The western blot assay indicated that 7b could decrease the phospho-Akt (S473) in a dose-dependent manner. Further experiments showed that 7b could induce apoptosis in MCF-7 cells. Four key hydrogen bonding interactions were found in the docking of 7b with PI3K kinase. All these results suggested that 7b is a potent PI3K inhibitor and could be considered as a potential candidate for the development of anticancer agents.