6480-87-1

Basic information

• Product Name: 2-Ethyl-2-phenylglycine Ethyl Ester
• Synonyms: 2-Ethyl-2-phenylglycine Ethyl Ester;2-AMino-2-phenylbutanoic Acid Ethyl Ester;2-AMino-2-phenyl-butyric Acid Ethyl Ester;α-AMino-α-ethyl-benzeneacetic Acid Ethyl Ester;ethyl 2-amino-2-phenylbutanoate
• CAS NO: 6480-87-1
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.26888
• Product Categories: Amines;Aromatics;Intermediates
• Mol File: 6480-87-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Solubility: Dichloromethane
• CAS DataBase Reference: 2-Ethyl-2-phenylglycine Ethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethyl-2-phenylglycine Ethyl Ester(6480-87-1)
• EPA Substance Registry System: 2-Ethyl-2-phenylglycine Ethyl Ester(6480-87-1)

Safety Data

• Hazardous Substances Data: 6480-87-1(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Oil

Uses

Intermediate in the preparation of Trimebutine metabolites.

Upstream product

• 27856-08-2 ethyl 2-amino-2-phenylbutanoate hydrochloride 
• 72651-17-3 phenylglycine ethyl ester hydrochloride 
• 142035-33-4 ethyl N-(phenylmethylene)glycinate 
• 2835-06-5 phenylglycin 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 96-10-6 diethylaluminium chloride 

Downstream Products

• 294882-34-1 2-(N-formyl)-methylamino-2-phenylbutanol 
• 78483-47-3 2-methylamino-2-phenylbutanol 
• 84333-59-5 Nortrimebutine 
• 294882-32-9 2-formylamino-2-phenyl-butyric acid ethyl ester 

Relevant articles and documents

Tandem N, N-Dialkylation Reaction of N-Trimethylsilyl α-Iminoesters Utilizing an Umpolung Reaction and Characteristics of the Silyl Substituent: Synthesis of Pyrrolidine, Piperidine, and Iminodiacetate

Umpolung reactions of N-trimethylsilyl α-iminoester with organometallics gave directly N-alkylaminoesters in high yields without the need for removing a protecting group at the nitrogen atom. Efficient syntheses of pyrrolidines, piperidines, and iminodiacetate derivatives were also developed via tandem N,N- or N,C-dialkylation reactions utilizing characteristics of the silyl substituent. Furthermore, under the influence of silica gel, the addition of an enolate to the imino nitrogen proceeded to give an iminodiacetate derivative.

Substituted 2, 4-imidazolidinedione compounds as pharmaceutical active ingredients

A substituted 2,4-imidazolidinedione compound corresponding to the formula I STR1 a process for production thereof and the use of these compounds in a pharmaceutical preparation are described. Substituents R1, R2, R3 and R4 have the same meaning as defined in the specification.