64846-47-5

Basic information

• Product Name: 4-nitrobenzene
• Synonyms: 4-nitrobenzene
• CAS NO: 64846-47-5
• Molecular Weight: 475.04
• Mol File: 64846-47-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitrobenzene(64846-47-5)
• EPA Substance Registry System: 4-nitrobenzene(64846-47-5)

Safety Data

• Hazardous Substances Data: 64846-47-5(Hazardous Substances Data)

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 407-25-0 trifluoroacetic anhydride 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 19169-99-4 (4-nitrophenyl)-λ3-iodanediyl diacetate 
• 64846-44-2 C₂₂H₄F₂₈INO₁₀ 
• 64846-41-9 C₁₄H₄F₁₂INO₁₀ 
• 64846-45-3 p-Bis-(acetoxy)-iodylnitrobenzol 
• 73178-10-6 4-nitrobenzene 
• 16825-79-9 1-iodyl-4-nitrobenzene 

Relevant articles and documents

Direct C-H α-Arylation of Enones with ArI(O2CR)2 Reagents

α-Arylation of α,β-unsaturated ketones constitutes a powerful synthetic transformation. It is most commonly achieved via cross-coupling of α-haloenones, but this stepwise strategy requires prefunctionalized substrates and expensive catalysts. Direct enone C-H α-arylation would offer an atom- and step-economical alternative, but such reports are scarce. Herein we report the metal-free direct C-H arylation of enones mediated by hypervalent iodine reagents. The reaction proceeds via a reductive iodonium Claisen rearrangement of in situ-generated β-pyridinium silyl enol ethers. The aryl groups are derived from ArI(O2CCF3)2 reagents, which are readily accessed from the parent iodoarenes. The reaction is tolerant of a wide range of substitution patterns, and the incorporated arenes maintain the valuable iodine functional handle. Mechanistic investigations implicate arylation via an umpoled "enolonium" species and show that the presence of a β-pyridinium moiety is critical for the desired C-C bond formation.

An Investigation of (Diacetoxyiodo)arenes as Precursors for Preparing No-Carrier-Added [18F]Fluoroarenes from Cyclotron-Produced [18F]Fluoride Ion

Treatment of (diacetoxyiodo)arenes (1a-1u) with cyclotron-produced [18F]fluoride ion rapidly affords no-carrier-added [18F]fluoroarenes (2a-2u) in useful yields and constitutes a new method for converting substituted iodoarenes into substituted [18F]fluoroarenes in just two steps.

A general and convenient preparation of [Bis(trifluoroacetoxy)iodo] perfluoroalkanes and [Bis(trifluoroacetoxy)iodo] arenes by oxidation of organic iodides using Oxone and trifluoroacetic acid

"Chemical Equation Presented" [Bis(trifiuoroacetoxy)iodo] perfiuoroalkanes CnF2n+1I(OC-OCF3)2 (n = 4, 6, 8, 10, 12) can be conveniently prepared by the oxidation of the corresponding perfluoroalkyl iodides with Oxone in trifluoroacetic acid at room temperature and subsequently converted to the stable [hydroxy(tosyloxy)-iodo] perfluoroalkanes, CnF2n+1I(OH)OTs, by treatment with p-toluenesulfonic acid. This general and convenient procedure has been further extended to the synthesis of various [bis(trifluoroacetoxy)iodo]arenes, ArI(OCOCF3)2.