648882-89-7

Basic information

• Product Name: (4-acetyl-cyclohexylmethyl)-carbamic acid tert-butyl ester
• Synonyms: (4-acetyl-cyclohexylmethyl)-carbamic acid tert-butyl ester
• CAS NO: 648882-89-7
• Molecular Weight: 255.357
• Mol File: 648882-89-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4-acetyl-cyclohexylmethyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-acetyl-cyclohexylmethyl)-carbamic acid tert-butyl ester(648882-89-7)
• EPA Substance Registry System: (4-acetyl-cyclohexylmethyl)-carbamic acid tert-butyl ester(648882-89-7)

Safety Data

• Hazardous Substances Data: 648882-89-7(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1197-18-8 trans-4-aminomethyl-cyclohexyl-carboxylic acid 
• 27687-14-5 trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid 
• 75-16-1 methylmagnesium bromide 
• 248953-91-5 Boc-Tra-N(OCH₃)CH₃ 

Downstream Products

• 648882-90-0 [4-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-cyclohexylmethyl]-carbamic acid tert-butyl ester 
• 570360-66-6 trans-tert-butyl [4-(1,8-naphthyridin-2-yl)cyclohexyl]methylcarbamate 

Relevant articles and documents

Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors

In this study, a series of novel hydroxyamidine derivatives were identified as potent and selective IDO1 inhibitors by structure-based drug design. Among them, compounds 13-15 and 18 exhibited favorable enzymatic and cellular activities. Compound 18 showed improved bioavailability in mouse, rat, and dog (F% = 44%, 58.8%, 102.1%, respectively). With reasonable in vivo pharmacokinetic properties, compound 18 was further evaluated in a transgenic MC38 xenograft mouse model. The combination of compound 18 with PD-1 monoclonal antibody showed a synergistic antitumor effect. These data indicated that compound 18 as a potential cancer immunotherapy agent should warrant further investigation.