648930-55-6

Basic information

• Product Name: 3-Pyridinemethanol, a-[[[2-(3,4-dichlorophenyl)ethyl]propylamino]methyl]-
• CAS NO: 648930-55-6
• Molecular Formula: C18H22Cl2N2O
• Molecular Weight: 353.291
• Mol File: 648930-55-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Pyridinemethanol, a-[[[2-(3,4-dichlorophenyl)ethyl]propylamino]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinemethanol, a-[[[2-(3,4-dichlorophenyl)ethyl]propylamino]methyl]-(648930-55-6)
• EPA Substance Registry System: 3-Pyridinemethanol, a-[[[2-(3,4-dichlorophenyl)ethyl]propylamino]methyl]-(648930-55-6)

Safety Data

• Hazardous Substances Data: 648930-55-6(Hazardous Substances Data)

Upstream product

• 91800-29-2 2-(propylamino)-1-(pyridin-3-yl)ethan-1-ol 
• 17694-68-7 3-(2-bromoacetyl)pyridine hydrobromide 
• 21581-45-3 2-(3,4-dichlorophenyl)ethanamine 
• 118838-57-6 (1-R)-2-bromo-1-(3-pyridinyl)-1-ethanol 
• 875811-94-2 2-[2-(3,4-dichlorophenyl)ethylamino]-1-pyridin-3-ylethanol 
• 123-38-6 propionaldehyde 
• 648424-11-7 2-(3,4-dichlorophenyl)-N-(2-hydroxy-2-pyridin-3-ylethyl)-N-propylacetamide 

Relevant articles and documents

Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14α-demethylase (CYP51)

Novel cholesterol biosynthesis inhibitors, a group of pyridylethanol(phenylethyl)amine derivatives, were synthesized. Sterol profiling assay in the human hepatoma HepG2 cells revealed that compounds target human lanosterol 14α-demethylase (CYP51). Structu

NOVEL DERIVATIVES OF PYRIDYLETHANOL (PHENYLETHYL) AMINES AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The novel derivatives of pyridylethanol (phenylethyl) amines of formula I are described wherein n is an integer from 1 to 4, R1 is a hydrogen atom, hydroxyl group or lower C1-6 alkoxy group R2 is a hydrogen atom or a straight or branched lower C1-6 alkyl group X, is hydrogen, fluorine, chlorine, bromine, hydroxyl group, trifluoromethyl group, 3,4-di-CI,2,4-di-CI or lower C1-6 alkoxy group, the enantiomers, diastereoisomers or racemates thereof or the physiologically acceptable acid addition salts thereof which are ligands of sigma receptors for inhibiting cholesterol biosynthesis and are thus appropriate for the treatment of hypercholesterolemia and hyperlipemia in humans. The greatest lowering of cholesterol was observed by 1-(d-pyridyl)-2-(N-(2-(3,4-dicholorophenyl)ethyl-N-propylamino)ethanol in the form of dihydrobromide salt (signature BK-35. 2HBr).