6493-80-7Relevant articles and documents
New entry to the enantioselective formation of substituted cyclohexenes bearing an all-carbon quaternary stereogenic center
Komine, Keita,Urayama, Yasuhiro,Hosaka, Taku,Fukuda, Hayato,Hatakeyama, Susumi,Ishihara, Jun
supporting information, p. 273 - 281 (2020/02/04)
Enantioselective formation of cyclohexene derivatives bearing an all-carbon quaternary stereogenic center is described. The racemic cyclohexenes are readily transformed to chiral substituted cyclohexenes in good yield with excellent enantioselectivity and diastereoselectivity by a palladium-mediated deracemization. The resulting products are promising synthetic intermediates of biologically active natural products. This protocol provides us with a new entry to the concise and scalable synthesis of multifunctionalized compounds.
Enones with Strained Double Bonds. 8. The Bicyclooctane Systems
House, Herbert O.,Haack, John L.,McDaniel, William C.,VanDerveer, Don
, p. 1643 - 1654 (2007/10/02)
The bicyclic enones bicyclooct-1-en-3-one (4) and 1-methylbicyclooct-5(6)-en-7-one (5) have been generated from various precursors and trapped by the addition of nucleophiles such as MeOH, PhSeH, or H2O.The bridgehead enone 5 has also been trapped as its cycloadduct 31 with furan.Pyrolysis of this cycloadduct 31 reformed the bridgehead enone 5 that was trapped as the cycloadduct 32.Related bridgehead enones 35 and 47 have also been generated as intermediates leading to products with bridgehead methoxy substituents.