64942-87-6

Basic information

• Product Name: 7-BROMO-2,3-DIHYDRO-1,8-NAPHTHYRIDIN-4(1H)-ONE
• Synonyms: 7-BROMO-2,3-DIHYDRO-1,8-NAPHTHYRIDIN-4(1H)-ONE;7-broMo-1,2,3,4-tetrahydro-1,8-naphthyridin-4-one
• CAS NO: 64942-87-6
• Molecular Formula: C₈H₇BrN₂O
• Molecular Weight: 227.06
• Mol File: 64942-87-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 190-192 °C(Solv: ethanol (64-17-5))
• Boiling Point: 442.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.83±0.1 g/cm3(Predicted)
• PKA: 5.85±0.40(Predicted)
• CAS DataBase Reference: 7-BROMO-2,3-DIHYDRO-1,8-NAPHTHYRIDIN-4(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-2,3-DIHYDRO-1,8-NAPHTHYRIDIN-4(1H)-ONE(64942-87-6)
• EPA Substance Registry System: 7-BROMO-2,3-DIHYDRO-1,8-NAPHTHYRIDIN-4(1H)-ONE(64942-87-6)

Safety Data

• Hazardous Substances Data: 64942-87-6(Hazardous Substances Data)

Usage

Description

7-Bromo-2,3-dihydro-1,8-naphthyridin-4(1H)-one, also known as BDN-76, is a synthetic derivative of the naphthyridine class of compounds with potential anti-tumor and anti-inflammatory properties. It is a potent inhibitor of the enzyme topoisomerase, which plays a crucial role in DNA replication and repair. BDN-76's unique structure and mechanism of action make it a promising candidate for the development of new cancer therapies and an interesting target for further research and development in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
7-Bromo-2,3-dihydro-1,8-naphthyridin-4(1H)-one is used as a potent inhibitor of topoisomerase enzyme for its potential anti-tumor and anti-inflammatory properties. It is being studied for its ability to target cancer cells and inhibit their growth, making it a promising candidate for the development of new cancer therapies.
Used in Medicinal Chemistry Research:
BDN-76 is used as a research compound to further understand its unique structure and mechanism of action. This knowledge can contribute to the development of more effective drugs and therapies for various diseases, particularly cancer.
Used in Drug Development:
7-Bromo-2,3-dihydro-1,8-naphthyridin-4(1H)-one is used as a starting point for the development of new drugs targeting topoisomerase enzymes. Its potential as an anti-tumor and anti-inflammatory agent makes it a valuable asset in the creation of novel pharmaceuticals to treat cancer and other related conditions.

Upstream product

• 68638-67-5 3-(6-bromopyridin-2-ylamino)propionic acid 

Downstream Products

• 76635-29-5 3-ethoxy-7-phenyl-5,6-dihydroquino<3,2-c><1,8>naphthyridine 
• 76635-30-8 3-hydroxy-7-phenyl-5,6-dihydroquino<3,2-c><1,8>naphthyridine 
• 76629-01-1 3-chloro-7-phenyl-5,6-dihydroquino<3,2-c><1,8>naphthyridine 
• 76629-08-8 3-Ethoxy-7-phenyl-4,5,12-triaza-benzo[a]anthracene 
• 76629-07-7 3-Bromo-7-phenyl-4,5,12-triaza-benzo[a]anthracene 
• 76629-09-9 7-Phenyl-4,5,12-triaza-benzo[a]anthracen-3-ol 
• 76629-06-6 3-Chloro-7-phenyl-4,5,12-triaza-benzo[a]anthracene 
• 676515-43-8 (RS)-(E)-4(1H)-[(2,3-epoxypropyl)oxyimino]-7-(4-t-butylphenoxy)-2,3-dihydro-1,8-naphthyridine 
• 676515-42-7 (RS)-(E)-4(1H)-[(2,3-epoxypropyl)oxyimino]-7-(4-chlorophenoxy)-2,3-dihydro-1,8-naphthyridine 
• 676515-38-1 (E)-4(1H)-hydroxyimino-7-(4-t-butylphenoxy)-2,3-dihydro-1,8-naphthyridine 
• 676515-41-6 (RS)-(E)-4(1H)-[(2,3-epoxypropyl)oxyimino]-7-phenoxy-2,3-dihydro-1,8-naphthyridine 
• 676515-37-0 (E)-4(1H)-hydroxyimino-7-(4-chlorophenoxy)-2,3-dihydro-1,8-naphthyridine 
• 676515-36-9 (E)-4(1H)-hydroxyimino-7-phenoxy-2,3-dihydro-1,8-naphthyridine 
• 676515-34-7 6-bromo-2,3-dihydro-1,8-naphthyridin-4(1H)-one 

Relevant articles and documents

PYRIDOPYRAZINES AND DERIVATIVES THEREOF AS ALK AND C-MET INHIBITORS

The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt form thereof, wherein A, L1, R1, R2, R3, R4, R5, R6, and X are as defined herein. The compounds of Formula I have ALK and/or c-Met inhibitory activity, and may b