64953-82-8

Basic information

• Product Name: 2-CHLORO-1-(4-ETHOXYPHENYL)ETHANONE
• Synonyms: ZINC 04200368
• CAS NO: 64953-82-8
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.6461
• Mol File: 64953-82-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 316.2 °C at 760 mmHg
• Flash Point: 136 °C
• Appearance: /
• Density: 1.149 g/cm³
• Vapor Pressure: 0.000416mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 2-CHLORO-1-(4-ETHOXYPHENYL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-1-(4-ETHOXYPHENYL)ETHANONE(64953-82-8)
• EPA Substance Registry System: 2-CHLORO-1-(4-ETHOXYPHENYL)ETHANONE(64953-82-8)

Safety Data

• Hazardous Substances Data: 64953-82-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-1-(4-ethoxyphenyl)ethanone is a chemical compound with the molecular formula C10H11O2Cl. It is a chlorinated ketone derivative and is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a colorless to pale yellow liquid with a sharp, pungent odor. The compound is soluble in organic solvents such as ethanol and acetone, but insoluble in water. It is important to handle this chemical with care, as it is considered to be hazardous and may cause skin and eye irritation, as well as respiratory issues if inhaled.

InChI:InChI=1/C10H11ClO2/c1-2-13-9-5-3-8(4-6-9)10(12)7-11/h3-6H,2,7H2,1H3

Upstream product

• 107-14-2 chloroacetonitrile 
• 103-73-1 Phenetole 
• 1676-63-7 4'-ethoxyacetophenone 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 75542-63-1 1-(4-ethoxy-phenyl)-2-thiocyanato-ethanone 
• 37764-15-1 6a-(4-ethoxy-phenyl)-6a,7-dihydro-6H-benzo[5,6][1,4]thiazino[3,4-b]quinazolin-12-one 
• 1003088-23-0 3-chloro-2-(4-ethoxyphenyl)-4-phenylquinoline 

Relevant articles and documents

Kinetics of Oxidation of Ketones by Trichloroisocyanuric Acid in Acid Medium: Anomalous Behaviour of Alkoxyacetophenones

Kinetics of oxidation of aliphatic, aryl aliphatic and cyclic ketones by trichloroisocyanuric acid has been studied in aqueous acetic acid medium in the presence of HClO4.The reaction is acid-catalysed exhibiting first order dependence each in and and zero order dependence in .This supports the acid catalyzed enolisation of ketone as the rate-determining step and reaction between enol and oxidant as the fast step.Alkoxyacetophenones exhibit an anomalous behaviour in that there is first order dependence on the halogenating agent.This has been attributed to the fact that in the case of alkoxyacetophenones the rates of halogenation may be less than the rates of enolisation.The decrease in dielectric constant of the medium slightly enhances the rate of reaction.The ρ? relationship in the case of acetophenones is linear with ρ as -0.2 indicating the simultaneous operation of equilibrium protonation of ketone and deprotonation of conjugate acid.Arrhenius activation parameters have been computed.A plausible mechanism consistent with the experimental results is postulated.