64968-23-6

Basic information

• Product Name: ethyl α-(2-phenyl-3-indolyl)-acetoacetate
• CAS NO: 64968-23-6
• Molecular Weight: 321.376
• Mol File: 64968-23-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl α-(2-phenyl-3-indolyl)-acetoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl α-(2-phenyl-3-indolyl)-acetoacetate(64968-23-6)
• EPA Substance Registry System: ethyl α-(2-phenyl-3-indolyl)-acetoacetate(64968-23-6)

Safety Data

• Hazardous Substances Data: 64968-23-6(Hazardous Substances Data)

Upstream product

• 1859-39-8 2-phenyl-N-hydroxyindole 
• 141-97-9 ethyl acetoacetate 
• 105-56-6 ethyl 2-cyanoacetate 

Relevant articles and documents

STUDIES ON TERTIARY AMINE OXIDES. LXXII. SOME NUCLEOPHILIC REACTIONS OF 1-HYDROXY-2-PHENYLINDOLE

1-Hydroxy-2-phenylindole (1) reacts with tosyl chloride and p-nitrobenzenesulfonyl chloride in DMF-pyridine to give the corresponding 2-phenyl-3-sulfonyloxyindole (2 and 4).Benzoyl chloride is less reactive, and 1-benzoyloxy-2-phenylindole (5) or 3-benzoyloxy-2-phenylindole (6) is formed, depending upon the reaction conditions. 3-Acetoxy-2-phenylindole (7) is also obtained by refluxing 1 with acetic anhydride or with acetyl chloride in DMF-pyridine.Treatment of 1 with tosyl chloride and then with 1-morpholinocyclohexene (9), ethyl acetoacetate (17) and ethyl cyanoacetate (20) in DMF-pyridine at room temperature affords 3-(2-oxocyclohexyl)-2-phenylindole (10), ethyl α-(2-phenyl-3-indolyl)acetoacetate (18) and ethyl α-(2-phenyl-3-indolyl)cyanoacetate (21) in 23.2, 41 and 61percent yields, respectively.Keywords: enehydroxylamine system; 1-acyloxy-2-phenylindole; 3-acyloxy-2-phenylindole; 1-morpholinocyclohexene; 3-(2-oxocyclohexyl)-2-phenylindole; ethyl α-(2-phenyl-3-indolyl)acetoacetate; ethyl α-(2-phenyl-3-indolyl)cyanoacetate