6505-08-4

Basic information

• Product Name: 1-(2-METHOXYPHENOXY)-2-PROPANAMINE
• Synonyms: [2-(2-methoxyphenoxy)-1-methyl-ethyl]amine;1-(2-METHOXYPHENOXY)-2-PROPANAMINE;OTAVA-BB 7020610572;UKRORGSYN-BB BBV-034209;1-(2-methoxyphenoxy)-2-propanamine(SALTDATA: FREE);[2-(2-methoxyphenoxy)-1-methylethyl]amine
• CAS NO: 6505-08-4
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.24
• Mol File: 6505-08-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 271.2°C at 760 mmHg
• Flash Point: 127.7°C
• Appearance: /
• Density: 1.038g/cm³
• Vapor Pressure: 0.00653mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 1-(2-METHOXYPHENOXY)-2-PROPANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-METHOXYPHENOXY)-2-PROPANAMINE(6505-08-4)
• EPA Substance Registry System: 1-(2-METHOXYPHENOXY)-2-PROPANAMINE(6505-08-4)

Safety Data

• Hazardous Substances Data: 6505-08-4(Hazardous Substances Data)

Usage

Classification

Secondary aliphatic amine

Propoxy group

A three-carbon chain (-OCH2CH2CH3) attached to the nitrogen atom

Methoxy group

An oxygen atom bonded to a methyl group (-OCH3) attached to the benzene ring

Benzene ring

A six-carbon ring with alternating single and double bonds

Pharmaceutical applications

Used as a potential intermediate or building block for the synthesis of drugs and pharmaceutical products

Suitability for drug design

Its chemical structure and functional groups make it suitable for manipulation and incorporation into new medications

Therapeutic potential

May have potential applications in the development of new medications for various therapeutic purposes

Additional uses

May also have uses in other fields such as organic synthesis and chemical research

InChI:InChI=1/C10H15NO2/c1-8(11)7-13-10-6-4-3-5-9(10)12-2/h3-6,8H,7,11H2,1-2H3

Upstream product

• 90-05-1 2-methoxy-phenol 
• 6437-45-2 1-(2-Methoxy-phenoxy)-propan-2-one oxime 
• 6437-46-3 1-(2-methoxyphenoxy)propan-2-one 

Downstream Products

• 70959-65-8 2-Chloro-5-{1-hydroxy-2-[2-(2-methoxy-phenoxy)-1-methyl-ethylamino]-ethyl}-benzenesulfonamide 

Relevant articles and documents

Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes

Ventricular cardiac arrhythmia (VA) arises in acquired or congenital heart disease. Long QT syndrome type-3 (LQT3) is a congenital form of VA caused by cardiac sodium channel (INaL) SCN5A mutations that prolongs cardiac action potential (AP) and enhances INaL current. Mexiletine inhibits INaL and shortens the QT interval in LQT3 patients. Above therapeutic doses, mexiletine prolongs the cardiac AP. We explored structure-activity relationships (SAR) for AP shortening and prolongation using dynamic medicinal chemistry and AP kinetics in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Using patient-derived LQT3 and healthy hiPSC-CMs, we resolved distinct SAR for AP shortening and prolongation effects in mexiletine analogues and synthesized new analogues with enhanced potency and selectivity for INaL. This resulted in compounds with decreased AP prolongation effects, increased metabolic stability, increased INaL selectivity, and decreased avidity for the potassium channel. This study highlights using hiPSC-CMs to guide medicinal chemistry and "drug development in a dish".

A (different) bright ammonia amide carbamate derivative and application thereof (by machine translation)

The invention belongs to the field of plant, relates to a general formula (I) is shown in a (different) bright ammonia amide carbamate derivatives and their pharmaceutically acceptable salt, wherein substituent R has the definition given in the specification, the invention also relates to the general formula (I) preparation of compounds of the, specifically for the preparation of the intermediate of its development and application of plant disease control. (by machine translation)

CARBAZOLYL-(4)-OXYPROPANOLAMINE COMPOUNDS AND THERAPEUTIC COMPOSITIONS

Carbazolyl-(4)-oxypropanolamine compounds of the formula where in R1 is hydrogen, lower alkanoyl or aroyl; R2 is hydrogen, lower alkyl or arylalkyl; R3 is hydrogen or lower alkyl; R4is hydrogen or lower alkyl, or when X is oxygen, R4 together with R5 can