65141-60-8

Basic information

• Product Name: 3-(2-CHLORO-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE
• Synonyms: 3-(2-chlorophenyl)-2-sulfanylidene-1H-quinazolin-4-one
• CAS NO: 65141-60-8
• Molecular Formula: C₁₄H₉ClN₂OS
• Molecular Weight: 288.76
• Mol File: 65141-60-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 439.7 °C at 760 mmHg
• Flash Point: 219.7 °C
• Appearance: /
• Density: 1.5 g/cm³
• Vapor Pressure: 6.23E-08mmHg at 25°C
• Refractive Index: 1.753
• CAS DataBase Reference: 3-(2-CHLORO-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-CHLORO-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE(65141-60-8)
• EPA Substance Registry System: 3-(2-CHLORO-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE(65141-60-8)

Safety Data

• Hazardous Substances Data: 65141-60-8(Hazardous Substances Data)

Usage

General Description

3-(2-chloro-phenyl)-2-mercapto-3H-quinazolin-4-one is a chemical compound that belongs to the quinazolinone class of compounds. It is a yellow crystalline powder that is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and bioactive compounds. 3-(2-CHLORO-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE has a quinazolinone core structure with a 2-mercapto substitution at the 2 position and a 2-chloro-phenyl substitution at the 3 position. It exhibits potent biological activities, including anti-inflammatory, antitumor, and antimicrobial properties, making it an important compound with potential therapeutic applications.

InChI:InChI=1/C14H9ClN2OS/c15-10-6-2-4-8-12(10)17-13(18)9-5-1-3-7-11(9)16-14(17)19/h1-8H,(H,16,19)

Upstream product

• 13037-24-6 N-(2-chlorophenyl)-methyl dithiocarbamic acid 
• 134-20-3 2-carbomethoxyaniline 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 2740-81-0 2-chlorophenylisothiocyanate 
• 118-92-3 anthranilic acid 
• 95-51-2 o-chloroaniline 

Downstream Products

• 1146625-14-0 C₂₀H₁₉ClN₂O₃S 
• 67811-52-3 4-(2-chlorophenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one 
• 66679-72-9 3-(2-chlorophenyl)-2-hydrazinylquinazolin-4(3H)-one 
• 70335-81-8 2-methylsulfanyl-3-(2-chlorophenyl)-3H-quinazolin-4-one 
• 70335-82-9 3-(2-chloro-phenyl)-2-ethylsulfanyl-3H-quinazolin-4-one 
• 140136-65-8 2,2'-dithiobis<3-(2-chlorophenyl)-4(3H)-quinazolinone> 
• 105362-79-6 3-Amino-2-(2-chloro-phenylamino)-3H-quinazolin-4-one 

Relevant articles and documents

Synthesis of New 1-Substituted-3-(3-(2-Chlorophenyl)-4-Oxo-3,4-Dihydrobenzopyrimidin-2-Ylamino)Isothioureas as Anti-HIV and Antibacterial Agents

In this study, a new benzopyrimidine analog was designed and synthesized by substituting 3-nitrophenyl ring and thiosemicarbazide nucleus at N-3 and C-2 positions of quinazoline ring, respectively. The title compounds, 1-substituted-3-(3-(2-chlorophenyl)-

Energy barriers to rotation in axially chiral quinazoline-4-ones

Axially chiral 2-thioxo-3-(o-aryl)-quinazolin-4-ones and 2-(benzylthio)-3-(o-aryl)-quinazolin-4-ones were synthesized and their energy barriers to rotation about the N3-Caryl bond were determined by thermal racemization of the separa

Divergent 2-Chloroquinazolin-4(3H)-one Rearrangement: Twisted-Cyclic Guanidine Formation or Ring-Fused N-Acylguanidines via a Domino Process

A highly efficient 2-chloroquinazolin-4(3H)-one rearrangement was developed that predictably generates either twisted-cyclic or ring-fused guanidines in a single operation, depending on the presence of a primary versus secondary amine in the accompanying diamine reagent. Exclusive formation of twisted-cyclic guanidines results from pairing 2-chloroquinazolinones with secondary diamines. Use of primary amine-containing diamines permits a domino quinazolinone rearrangement/intramolecular cyclization, gated through (E)-twisted-cyclic guanidines, to afford ring-fused N-acylguanidines. This scalable, structurally tolerant transformation generated 55 guanidines and delivered twisted-cyclic guanidines with robust plasma stability and an abbreviated total synthesis of an antitumor ring-fused guanidine (4 steps, 55 % yield).