65224-66-0

Basic information

• Product Name: 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE
• Synonyms: 2-CHLORO-6-METHYL-5-NITROPYRIMIDIN-4-OL;2-CHLORO-6-METHYL-5-NITROURACIL;2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE;2-Chloro-6-methylnitro-4(1H)-pyrimidinone;2-chloro-6-methyl-5-nitro-3H-pyrimidin-4-one;6-chloro-2-Methyl-5-nitropyriMidin-4-ol;2-chloro-6-Methyl-1-nitro-1,4-dihydropyriMidin-4-one;2-Chloro-4-hydroxy-6-methyl-5-nitropyrimidine
• CAS NO: 65224-66-0
• Molecular Formula: C₅H₄ClN₃O₃
• Molecular Weight: 189.56
• Mol File: 65224-66-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 276℃
• Flash Point: 121℃
• Appearance: Gray/Solid
• Density: 1.80
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE(65224-66-0)
• EPA Substance Registry System: 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE(65224-66-0)

Safety Data

• Hazardous Substances Data: 65224-66-0(Hazardous Substances Data)

Usage

General Description

2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE is a chemical compound with the molecular formula C5H4ClN3O3. It is a yellow crystalline solid with a molecular weight of 175.56 g/mol. 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE is a derivative of pyrimidine and has a chloro, methyl, and nitro group attached to the pyrimidine ring. It is commonly used in the synthesis of pharmaceuticals and agrochemicals. 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE is also utilized as an intermediate in organic synthesis and can undergo various chemical reactions to produce different derivatives and products.

InChI:InChI=1/C5H4ClN3O3/c1-2-3(9(11)12)4(10)8-5(6)7-2/h1H3,(H,7,8,10)

Upstream product

• 16632-21-6 6-methyl-5-nitropyrimidine-2,4-diol 
• 13162-26-0 2,4-dichloro-6-methyl-5-nitropyrimidine 

Downstream Products

• 917596-58-8 2-ethoxy-6-methyl-5-nitro-pyrimidin-4-ol 
• 13162-24-8 2-amino-4-chloro-5-nitro-6-methylpyrimidine 
• 937365-20-3 C₁₃H₁₃ClN₄O₂ 
• 937365-36-1 C₁₂H₉Cl₃N₄O₂ 
• 937365-35-0 C₁₂H₉Cl₃N₄O₂ 
• 937365-34-9 C₁₂H₉ClF₂N₄O₂ 
• 937365-33-8 C₁₃H₉ClF₄N₄O₂ 
• 937365-32-7 C₁₂H₉Cl₂FN₄O₂ 
• 937365-31-6 C₁₂H₉ClF₂N₄O₂ 
• 937365-30-5 C₁₃H₁₃ClN₄O₃ 
• 937365-29-2 C₁₃H₁₀ClF₃N₄O₃ 
• 937365-27-0 C₁₄H₉ClF₆N₄O₂ 
• 937365-26-9 C₁₃H₁₀ClF₃N₄O₃ 

Relevant articles and documents

SAR studies on a novel series of human cytomegalovirus primase inhibitors

A novel series of imidazolylpyrimidines were found to possess inhibitory activity against the human CMV UL70 primase. Extensive SAR studies on an HTS lead led to potent, orally bioavailable compounds with anti-CMV IC50 values of 150 nM in both

Arylsulfonic acid salts of pyrimidine-based antiviral

Salts of pyrimidine derivatives are provided having the formula: wherein R represents hydrogen, methyl or ethyl; Z represents a substituted or unsubstituted 1-piperidinyl, a substituted or unsubstituted 4-morpholinyl, or a substituted or unsubstituted 1-pyrrolidinyl; and Ar represents a substituted or unsubstituted phenyl or a substituted or unsubstituted naphthyl. These salts are particularly useful as antiviral agents (e.g., to treat CMV infections).