65300-29-0

Basic information

• Product Name: 3-Buten-2-one, 4-(4-fluorophenyl)-, (3E)-
• CAS NO: 65300-29-0
• Molecular Formula: C10H9FO
• Molecular Weight: 164.179
• Mol File: 65300-29-0.mol
• Article Data: 88

Chemical Properties

• CAS DataBase Reference: 3-Buten-2-one, 4-(4-fluorophenyl)-, (3E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Buten-2-one, 4-(4-fluorophenyl)-, (3E)-(65300-29-0)
• EPA Substance Registry System: 3-Buten-2-one, 4-(4-fluorophenyl)-, (3E)-(65300-29-0)

Safety Data

• Hazardous Substances Data: 65300-29-0(Hazardous Substances Data)

Upstream product

• 1262991-68-3 tert-butyl 2-(4-fluorophenyl)diazene-1-carboxylate 
• 1589517-78-1 tetra-n-butylammonium 4-fluorophenylazocarboxylate 
• 78-94-4 methyl vinyl ketone 
• 459-57-4 4-fluorobenzaldehyde 
• 67-64-1 acetone 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 371-40-4 4-fluoroaniline 
• 459-56-3 4-fluorobenzylic alcohol 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 459-46-1 4-Fluorobenzyl bromide 
• 2248-13-7 1-(but-3-en-1-yl)-4-fluorobenzene 
• 1067-71-6 Diethyl (2-oxopropyl)phosphonate 
• 1092986-09-8 (E)-4-(4-fluorophenyl)but-3-en-2-ol 

Downstream Products

• 81467-68-7 N'-[(E)-3-(4-Fluoro-phenyl)-1-methyl-prop-2-en-(E)-ylidene]-N,N-dimethyl-hydrazine 
• 251443-18-2 4,5-dihydro-5-(4-fluorophenyl)-3-methyl-1-(4-methylsulphonylphenyl)-1H-pyrazole 
• 63416-61-5 4-(4-fluorophenyl)-2-butanone 
• 1092986-09-8 (E)-4-(4-fluorophenyl)but-3-en-2-ol 
• 1613507-01-9 (R,E)-4-(4-fluorophenyl)but-3-en-2-yl pivalate 
• 1401081-56-8 (R,E)-4-(4-fluorophenyl)but-3-en-2-ol 
• 122252-55-5 β-(4-Fluorophenyl)-α-(2-methyl-1-oxopropyl)-Δ-oxohexanoic acid, ethyl ester 
• 63416-62-6 5-{2-[3-(4-Fluoro-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzoic acid methyl ester 
• 1254182-93-8 (R)-4-(4-fluorophenyl)-4-(2-methyl-1H-indol-3-yl)butan-2-one 
• 1258422-81-9 (1S,6R)-1'-benzyl-6-(4-fluorophenyl)-2-methylspiro[cyclohex[2]ene-1,3'-indoline]-2',4-dione 
• 1258422-94-4 (1S,6R)-6-(4-fluorophenyl)-1',2-dimethylspiro[cyclohex[2]ene-1,3'-indoline]-2',4-dione 
• 1262896-34-3 (2R,3R)-ethyl 2-fluoro-3-(4-fluorophenyl)-2-nitro-5-oxohexanoate 
• 1262896-22-9 (2S,3R)-ethyl 2-fluoro-3-(4-fluorophenyl)-2-nitro-5-oxohexanoate 

Relevant articles and documents

Polysubstituted Indole Synthesis via Palladium/Norbornene Cooperative Catalysis of Oxime Esters

Polysubstituted indoles are prevalent in pharmaceuticals, agrochemicals, and organic materials. Presented herein is the fact that polyfunctionalized indoles can be efficiently constructed from easily accessible oxime esters and aryl iodides, involving a palladium/norbornene synergistic synthesis. The reaction is enabled by a unique class of electrophiles in palladium/norbornene cooperative catalysis, which are oxime esters derived from simple ketone. The broad substrate scope and high functional group tolerance could make this method attractive for the synthesis of polysubstituted indoles.

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.

Piperlongumine derivative as well as preparation method and application thereof

The invention discloses a Piperlongumine derivative as well as a preparation method and application thereof. The Piperlongumine derivative has the following structure: the Piperlongumine derivative provided by the invention contains a plurality of Michael addition receptor units, and the novel structure improves the electrophilicity, so that the Piperlongumine derivative has good protein targetingpotential, and the Piperlongumine derivative has a good inhibition effect on thioredoxin reductase; in an antitumor bioactive in-vitro screening experiment, the derivative also has a certain inhibition effect on the growth of tumor cells, and meanwhile, the derivative has an effect of promoting the generation of active oxygen in A549 human lung cancer cells.