65321-30-4

Basic information

• Product Name: N-tert-Butylisonicotinamide
• Synonyms: N-tert-Butylisonicotinamide
• CAS NO: 65321-30-4
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23096
• Mol File: 65321-30-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: N-tert-Butylisonicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butylisonicotinamide(65321-30-4)
• EPA Substance Registry System: N-tert-Butylisonicotinamide(65321-30-4)

Safety Data

• Hazardous Substances Data: 65321-30-4(Hazardous Substances Data)

Usage

General Description

N-tert-Butylisonicotinamide is a chemical compound known for its biological activity. It is characterized by the presence of an isonicotinamide group linked to a tert-butyl group. The exact properties, including its melting point, boiling point, and solubility, can vary based on factors like purity and pH. The substance is often used in scientific research, particularly in fields like biochemistry and pharmacology. It can be prepared through specific organic synthesis processes, though safety precautions should be taken due to potential hazards associated with its components.

Upstream product

• 1570-45-2 isonicotinic acid ethylester 
• 75-64-9 tert-butylamine 
• 872-85-5 pyridine-4-carbaldehyde 
• 24390-63-4 4-(2-tert-butyl-oxaziridin-3-yl)-pyridine 
• 504-24-5 4-aminopyridine 
• 119072-55-8 tert-butylisonitrile 
• 100-48-1 pyridine-4-carbonitrile 
• 75-65-0 tert-butyl alcohol 
• 55-22-1 pyridine-4-carboxylic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 39178-35-3 isonicotinoyl chloride hydrochloride 

Downstream Products

• 1071017-64-5 N-tert-butyl-3-methylisonicotinamide 
• 1071136-35-0 1-[3-(2-cyclohexylaminopyridin-4-yl)-4-methyl-[2,6]naphthyridin-1-yl]piperidine-4-carboxylic acid isobutylamide 
• 1071137-64-8 1-[3-(2-chloropyridin-4-yl)-4-(4-fluorophenyl)-[2,6]naphthyridin-1-yl]piperidine-4-carboxylic acid isobutylamide 
• 1071137-53-5 4-[3-(2-chloropyridin-4-yl)-4-phenyl-[2,6]naphthyridin-1-yl]piperazine-1-carboxylic acid tert-butyl ester 
• 1071129-72-0 cyclohexyl-{4-[1-(4-methylpiperazin-1-yl)[2,6]naphthyridin-3-yl]pyridin-2-yl}amine 
• 1071137-68-2 cyclohexyl-[3,5-dibromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]amine 
• 1071137-66-0 [5-bromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine 
• 1071137-73-9 [3-chloro-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine 
• 1071137-70-6 [5-chloro-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine 
• 1071137-15-9 cyclohexyl-[4-(1-methoxy-[2,6]naphthyridin-3-yl)pyridin-2-yl]amine 
• 1071137-19-3 3-(2-cyclohexylaminopyridin-4-yl)-[2,6]naphthyridin-1-ol 
• 1071137-22-8 [4-(1-chloro[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine 
• 1329663-63-9 C₃₈H₃₂N₂O 
• 1021464-09-4 N-(tert-butyl)-3-[(hydroxy)(3,4,5-trimethoxyphenyl)methyl]pyridine-4-carboxamide 

Relevant articles and documents

Weak base-promoted selective rearrangement of oxaziridines to amidesviavisible-light photoredox catalysis

The selective rearrangement of oxaziridines to amidesviaa single electron transfer (SET) pathway is unexplored. In this study, we present a weak base-promoted selective rearrangement of oxaziridines to amidesviavisible-light photoredox catalysis. The developed method shows excellent functional group tolerance with a broad substrate scope and good to excellent yields. Furthermore, control experiments and density functional theory (DFT) calculations are performed to gain insight into the reactivity and selectivity.

Highly efficient synthesis of amides via Ritter chemistry with ionic liquids

The utility of Br?nsted-acidic imidazolium ionic liquid [BMIM(SO3H)][OTf] as catalyst for the high yield synthesis of a wide variety of amides under mild conditions via the Ritter reaction of alcohols with nitriles has been demonstrated. As alternative methods for the carbocation generation step, NOPF6 immobilized in [BMIM][PF6] ionic liquid was used in the Ritter reaction of bromides with nitriles and for the synthesis of adamantyl amides from adamantane and nitriles.

[2, 6] NAPHTHYRIDINES USEFUL AS PROTEIN KINASE INHIBITORS

The present invention provides a compound of formula I: (formula I) said compound is inhibitor of selective subset of kinases belonging to the AGC or calmodulin kinase family, such as for example MARK1/2/3, PKD-1/2/3, PKN-1/2, CDK-9, CaMKII, ROCK-I/II, inhibitors of histone deacetylase (HDAC) phosphorylation, or inhibitors of other kinases. Finally, the present invention also provides a pharmaceutical composition.