65370-33-4 Usage
Medicinal use
Treats type 2 diabetes.
Function
Increases insulin production and decreases glucose production by the liver.
Drug class
Dipeptidyl peptidase-4 (DPP-4) inhibitors.
Administration
Often prescribed in combination with diet and exercise.
Check Digit Verification of cas no
The CAS Registry Mumber 65370-33-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,3,7 and 0 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 65370-33:
(7*6)+(6*5)+(5*3)+(4*7)+(3*0)+(2*3)+(1*3)=124
124 % 10 = 4
So 65370-33-4 is a valid CAS Registry Number.
65370-33-4Relevant articles and documents
Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers
Lloyd, John,Finlay, Heather J.,Vacarro, Wayne,Hyunh, Tram,Kover, Alexander,Bhandaru, Rao,Yan, Lin,Atwal, Karnail,Conder, Mary Lee,Jenkins-West, Tonya,Shi, Hong,Huang, Christine,Li, Danshi,Sun, Huabin,Levesque, Paul
scheme or table, p. 1436 - 1439 (2010/07/02)
Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.
