6538-02-9Relevant articles and documents
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation
Sepe, Valentina,Di Leva, Francesco Saverio,D'Amore, Claudio,Festa, Carmen,De Marino, Simona,Renga, Barbara,D'Auria, Maria Valeria,Novellino, Ettore,Limongelli, Vittorio,D'Souza, Lisette,Majik, Mahesh,Zampella, Angela,Fiorucci, Stefano
, p. 3091 - 3115 (2014/07/08)
In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaffold a number of derivatives were prepared and evaluated for their ability to activate the PXR by assessing transactivation and quantifying gene expression. Our study reveals that ergost-5-en-3β-ol (4) induces PXR transactivation in HepG2 cells and stimulates the expression of the PXR target gene CYP3A4. To shed light on the molecular basis of the interaction between these ligands and PXR, we investigated, through docking simulations, the binding mechanism of the most potent compound of the series, 4, to the PXR. Our findings provide useful functional and structural information to guide further investigations and drug design.
Marine sterols. XXI. Isolation of (24S)-3β-hydroxyergost-5-en-21-oic acid from a Sclerophytum sp. of soft coral
Kobayashi,Haribabu,Anjaneyulu
, p. 233 - 234 (2007/10/02)
The lipid extract of the Sclerophytum sp. of soft coral, collected off the coast of the Andaman and Nicobar Islands, afforded a new sterol 1a. The structure of 1a was shown to be (24S)-3β-hydroxyergost-5-en-21-oic acid, the first member of a class of mari
