654676-72-9

Basic information

• Product Name: 3H-1,2,3-Triazolo[4,5-b]pyridine, 3-[[(4-nitrophenyl)sulfonyl]oxy]-
• CAS NO: 654676-72-9
• Molecular Formula: C11H7N5O5S
• Molecular Weight: 321.273
• Mol File: 654676-72-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3H-1,2,3-Triazolo[4,5-b]pyridine, 3-[[(4-nitrophenyl)sulfonyl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-1,2,3-Triazolo[4,5-b]pyridine, 3-[[(4-nitrophenyl)sulfonyl]oxy]-(654676-72-9)
• EPA Substance Registry System: 3H-1,2,3-Triazolo[4,5-b]pyridine, 3-[[(4-nitrophenyl)sulfonyl]oxy]-(654676-72-9)

Safety Data

• Hazardous Substances Data: 654676-72-9(Hazardous Substances Data)

Upstream product

• 39968-33-7 1-hydroxy-7-aza-benzotriazole 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 164861-48-7 Z-L-Phe-L-Val-L-Pro-NH₂ 
• 154561-21-4 Z-Aib-OAt 

Relevant articles and documents

Organophosphorus and Nitro-Substituted Sulfonate Esters of 1-Hydroxy-7-azabenzotriazole as Highly Efficient Fast-Acting Peptide Coupling Reagents

Organophosphorus esters 9, 10, 14, and 15 prepared via reaction of diethyl- and diphenylphosphoryl chloride, di(o-tolyl)phosphinyl chloride, and 2,8-dimethylphenoxaphosphinyl chloride with HOAt are excellent coupling reagents for peptide synthesis which are generally superior to their uronium/guanidinium analogues and HOBt- or HODhbt-derived phosphate ester counterparts in minimizing loss of configuration during segment coupling. The phosphinyl analogues are more shelf-stable than the phosphoryl systems. The new reagents have been tested in segment couplings leading to two tripeptides (20, 21) and a hexapeptide 22. Outstanding utility is also shown for the solid-phase assembly of the ACP decapeptide. Similar results were obtained with the 2- and 4-nitro- and 2,4-dinitrophenylsulfonyl esters derived from HOAt.