65473-14-5 Usage
Description
Naftifine hydrochloride, also known as Naftin, is a white crystalline powder that is soluble in polar solvents such as ethanol and methylene chloride. It is a potent antifungal agent that acts by inhibiting squalene epoxidase, demonstrating good activity against various fungal species, including Trichophyton, Epidermophyton, Microsporum, and Aspergillus. Naftifine hydrochloride is the prototype of a significantly improved series of antifungal agents, with a broad antifungal spectrum and low toxicity.
Uses
Used in Pharmaceutical Industry:
Naftifine hydrochloride is used as an antibiotic drug for the treatment of dermatophyte infections, superficial moniliasis, onychomycosis, and skin conditions caused by achorion, microspore, and epidermis Trichophyton. It is particularly effective in treating erasing mycosis of the lower breast, erasing mycosis between fingers (toes), the buttocks, and the groin.
Used in Antifungal Treatments:
Naftifine hydrochloride is used as an antifungal (topical) agent for treating ringworm, athlete's foot, and jock itch. It is supplied in a 1% concentration in a cream and in a gel for topical application. Although not officially approved for these uses, naftifine has shown efficacy in treating ringworm of the beard, ringworm of the scalp, and tinea versicolor.
Used in Antifungal Research:
Naftifine hydrochloride serves as a prototype for the development of new and improved antifungal agents, such as SF 86-327, where the phenyl group of naftifine has been replaced by t-butylacetylene. This research contributes to the advancement of antifungal treatments and the development of more effective drugs against fungal infections.
Brand Names:
Naftifine hydrochloride is available under the brand names Naftin (Merz) and EXODERIL.
Local antifungal agents
Naphthalene hydrochloride, also known as cinnamonyl methylamine, naphthalene, and naphthalene hydrochloride, is currently one of the commonly used drugs for fungal infection in Department of Dermatology, belonging to the local antifungal agents of acrylamines. It has bactericidal effect on the dermatophytes (Trichophyton, Microsporum and epidermis Trichophyton). It has bacteriostasis against Malassezia, Candida and other yeasts. It also has local bactericidal effect on Gram-positive and negative bacteria. The mechanism of its action is to inhibit the fungal squalene cyclooxygenase. It interferes with the biosynthesis of ergosterol in fungal cell wall. It affects the lipid metabolism of fungi and causes the damage or death of fungal cells to play a bactericidal and bacteriostasis effect. It is suitable for dermatophytosis caused by sensitive fungi, such as tinea corporis, tinea pedis, tinea capitis, onychomycosis, tinea versicolor, superficial candidiasis as well as erasing fungal disease in the skin folds. For the the external application of 1% Naftifine Hydrochloride Ointment on the skin by thehealthy people, about 3% to 6% of the doses can be absorbed.The concentration of naphthofinn on the surface of the skin at a single dose within 24 hours is sufficient to inhibit the growth of dermatitis. Naftifine can be converted to at least three metabolites through the oxidation of benzene ring and naphthalene and N- alkylation in the body. About 40% to 60% of the drugs in the body are excreted in the form of the original and metabolite form into the urine, and the rest is excreted into the feces by the bile. The half-life of the skin external use of naftifine is about 2~3 days.
Usage and dosage: external use. For the skin infection, usually 1 times /d, and gently rub. The skin within 2.5cm centred on the infection should be coated with the drug. For erasing fungal disease, a ribbon gauze containing this product can be disposed at night in wrinkles.
Duration of treatment: 2-4 weeks for dermatophyte infection and 8 weeks in severe cases; 4 weeks for superficial moniliasis;6 months for Onychomycosis ; 2 weeks for pityriasis versicolor. For the prevention of recurrence, the treatment continues for about 2 weeks after all the signs of infection have disappeared.
Originator
Sandoz (Switzerland)
Clinical Use
Naftifine hydrochloride (Naftin) is available for topical
use only in the treatment of cutaneous dermatophyte
and Candida infections; it is as effective as topical
azoles for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 65473-14-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,4,7 and 3 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 65473-14:
(7*6)+(6*5)+(5*4)+(4*7)+(3*3)+(2*1)+(1*4)=135
135 % 10 = 5
So 65473-14-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
