65489-00-1

Basic information

• Product Name: Piperazine, 1-[3-(phenylthio)propyl]-
• CAS NO: 65489-00-1
• Molecular Formula: C13H20N2S
• Molecular Weight: 236.381
• Mol File: 65489-00-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-[3-(phenylthio)propyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-[3-(phenylthio)propyl]-(65489-00-1)
• EPA Substance Registry System: Piperazine, 1-[3-(phenylthio)propyl]-(65489-00-1)

Safety Data

• Hazardous Substances Data: 65489-00-1(Hazardous Substances Data)

Upstream product

• 110-85-0 piperazine 
• 4911-65-3 3-chloropropyl phenyl sulfide 
• 108-98-5 thiophenol 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 95250-49-0 3,7-dihydro-1,3-dimethyl-7-<4-<4-<3-(phenylthio)propyl>piperazin-1-yl>-2-butenyl>-1H-purine-2,6-dione 
• 95250-61-6 3,7-Dimethyl-1-{3-[4-(3-phenylsulfanyl-propyl)-piperazin-1-yl]-propyl}-3,7-dihydro-purine-2,6-dione 
• 79730-42-0 3,7-dihydro-1,3-dimethyl-7-<3-<4-<3-(phenylthio)propyl>piperazin-1-yl>propyl>-1H-purine-2,6-dione 
• 86590-99-0 3,7-dihydro-3,7-dimethyl-1-<3-<4-<3-(phenylthio)propyl>piperazin-1-yl>-2-hydroxypropyl>-1H-purine-2,6-dione 
• 95250-51-4 1,3-Dimethyl-7-{2-oxo-2-[4-(3-phenylsulfanyl-propyl)-piperazin-1-yl]-ethyl}-3,7-dihydro-purine-2,6-dione 
• 79712-55-3 3,7-dihydro-1,3-dimethyl-7-<3-<4-<3-(phenylthio)propyl>piperazin-1-yl>-2-hydroxypropyl>-1H-purine-2,6-dione 

Relevant articles and documents

New Antihistaminic Theophylline or Theobromine Derivatives

A series of 3,4-dihydro-1,3-dimethyl-7--1H-purine-2,6-diones and 3,7-dihydro-3,7-dimethyl-1--1H-purine-2,6-diones was synthesized and evaluated for antihistaminic activity.Some of them displayed good inhibition of both histamine-induced bronchospasm in the anesthetized guinea pig at 10 μ/kg by the intravenous route and of passive cutaneous anaphylaxis in the rat at 10 mg/kg by the oral route.Comparison of the two most active compounds revealed a higher antihistaminic activity with the compounds containing a (phenylthio)propyl group (1 and 2) as compared with that containing a phenoxy group.Compound 2 piperazin-1-yl>-2-hydroxypropyl>-1H-purine-2,6-dione> was selected for clinical trials on the basis of a comparative pharmacological study with chloropheniramine, ketotifen, promethazine, and theophylline.

Piperazine derivatives of theophylline

New compounds of the formula STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein M is selected from the group consisting of hydrogen, morpholino, benzylamino, di-n-lower alkylamine, n-lower alkylamine, and aryl piperazino; Z1 and Z2 are each independently selected from the group consisting of CH2, CHOB and C=O, wherein B is selected from the group consisting of hydrogen and alkanoyl; Y is oxygen or sulfur; n is an integer from 0-4 but cannot be zero when Z1 is CHOB; m is an integer from 0-4 but cannot be zero when Z2 is CHOB, or when m is hydrogen; R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, trifluoromethyl, alkyl or alkoxy; and R4 and R5 are each independently lower alkyl, with the proviso that both R4 and R5 cannot be methyl when M is hydrogen; are antihistamines and are therefore useful in the treatment of respiratory diseases including asthma, hay fever, allergies and the common cold. They are also vasodilators.

Piperazine alkanols

This invention relates to variously substituted piperazine derivatives. S compounds possess therapeutically useful vasodilator properties.