655-15-2

Basic information

• Product Name: 2-Bromo-2'-fluoroacetophenone
• Synonyms: BUTTPARK 35\01-51;2-BROMO-2'-FLUOROACETOPHENONE;2-FLUOROPHENACYL BROMIDE;2-BROMO-2'-DIFLUOROACETOPHENONE;Ethanone, 2-bromo-1-(2-fluorophenyl)- (9CI);2-Fluorophenacylbromide98%;2-Bromo-1-(2-fluoro-phenyl)-ethanone;2-Bromo-2'-fluoroacetophenone, 2-Bromo-1-(2-fluorophenyl)ethan-1-one
• CAS NO: 655-15-2
• Molecular Formula: C₈H₆BrFO
• Molecular Weight: 217.04
• Product Categories: ACETYLHALIDE;Ketone;Aromatics
• Mol File: 655-15-2.mol
• Article Data: 64

Chemical Properties

• Melting Point: 25-27
• Boiling Point: 83-85
• Flash Point: >110 °C
• Appearance: Liquid
• Density: 1.574 g/mL at 25 °C
• Refractive Index: n20/D1.563
• Storage Temp.: Keep Cold
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Sensitive: Lachrymatory
• Stability: Unstable in DMSO
• CAS DataBase Reference: 2-Bromo-2'-fluoroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-2'-fluoroacetophenone(655-15-2)
• EPA Substance Registry System: 2-Bromo-2'-fluoroacetophenone(655-15-2)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38-34
• Safety Statements: 26-36/37/39-45-27
• RIDADR: UN 3261 8 / PGIII
• WGK Germany: 3
• HazardClass: LACHRYMATOR, CORROSIVE
• PackingGroup: III
• Hazardous Substances Data: 655-15-2(Hazardous Substances Data)

Usage

Chemical Properties

Liquid

Uses

A new class of acetophenone-based cinchona alkaloid-derived quaternary ammonium salts were prepared and evaluated as phase-transfer catalysts in the enantioselective alkylation of glycine imine ester.

InChI:InChI=1/C8H7FO2S/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 450-95-3 2-fluoroacetophenone 
• 445-27-2 2'-Fluoroacetophenone 
• 1246224-44-1 1-(bromoethynyl)-2-fluorobenzene 

Downstream Products

• 129486-34-6 4-(2-fluorophenyl)-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole 
• 121041-72-3 2-(2-Fluoro-phenyl)-6-(2-methoxy-phenoxy)-imidazo[1,2-b]pyridazin-3-ol 
• 122479-50-9 2-(2-Fluoro-phenyl)-6-(3-methoxy-benzylamino)-imidazo[1,2-b]pyridazin-3-ol 
• 121041-80-3 2-(2-Fluoro-phenyl)-6-(3-methoxy-benzylsulfanyl)-imidazo[1,2-b]pyridazin-3-ol 
• 31915-26-1 3-(2-fluorophenyl)-3-oxo-propanenitrile 
• 63188-83-0 2-fluoro-α-(2-methyl-5-methoxyphenoxy)acetophenone 
• 1033005-69-4 (S)-2-bromo-1-(2-fluorophenyl)ethanol 
• 1051372-53-2 methyl 3-(4-(2-fluorophenyl)oxazol-2-yl)propanoate 
• 1207476-98-9 C₃₂H₂₄FN₃O₃ 
• 1289638-15-8 LDN-193594 
• 1289638-20-5 C₁₅H₁₁FN₄OS 
• 1289638-28-3 C₁₆H₁₃FN₄OS 
• 1393890-96-4 (Z)-5-(4-(2-(2-fluorophenyl)-2-oxoethoxy)benzylidene)-2-thioxothiazolidin-4-one 
• 1393891-09-2 (Z)-2-(5-(4-(2-(2-fluorophenyl)-2-oxoethoxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid 

Relevant articles and documents

Based on isoxazole substitution of benzamide derivatives and anti-prostate cancer drug applications

The present invention discloses a class (I), formula (II) structure based on isoxazole substituted benzamide derivatives and antiprostate cancer drug applications, such isoxazole substituted benzamide derivatives, can effectively inhibit the activity of a

High Chemo-/Stereoselectivity for Synthesis of Polysubstituted Monofluorinated Pyrimidyl Enol Ether Derivatives

A novel intramolecular Smiles rearrangement of α-fluoro-β-keto-pyrimidylsulfones (usually used as a carbon nucleophile) was developed, providing a versatile avenue for synthesis of tri/tetra-substituted monofluorinated pyrimidyl enol ethers. Among these, diverse (Z)-monofluorovinylsulfones and sulfinates were efficiently assembled by adding extra electrophile and fine-tuning reaction conditions. The process is triggered by a keto-enol tautomerism from enol oxyanion to pyrimidine 2-carbon, completely different from the classical carbon nucleophilic addition reaction approach.

Base-Catalyzed Intramolecular Defluorination/O-Arylation Reaction for the Synthesis of 3-Fluoro-1,4-oxathiine 4,4-Dioxide

A novel process involving base-catalyzed intramolecular defluorination/O-arylation of readily available α-fluoro-β-one-sulfones was realized and provided a series of 3-fluoro-1,4-oxathiine 4,4-dioxide derivatives in good to excellent yields. Unlike traditional defluorination reactions with stoichiometric base as the deacid reagent, this process is triggered by a catalytic amount of base (TMG: tetramethylguanidine) and molecular sieves serve as both an adsorbent to remove HF acid and an activator to assist C-F bond cleavage.