655-25-4

Basic information

• Product Name: 2,2,2-Trifluoro-1-phenylethanone oxime
• Synonyms: 2,2,2-Trifluoro-1-phenylethanone oxime
• CAS NO: 655-25-4
• Molecular Formula: C₈H₆F₃NO
• Molecular Weight: 189.13
• Mol File: 655-25-4.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 194.1°C at 760 mmHg
• Flash Point: 71.2°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.281mmHg at 25°C
• Refractive Index: 1.461
• CAS DataBase Reference: 2,2,2-Trifluoro-1-phenylethanone oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-1-phenylethanone oxime(655-25-4)
• EPA Substance Registry System: 2,2,2-Trifluoro-1-phenylethanone oxime(655-25-4)

Safety Data

• Hazardous Substances Data: 655-25-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6F3NO/c9-8(10,11)7(12-13)6-4-2-1-3-5-6/h1-5,13H/b12-7-

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 

Downstream Products

• 40618-87-9 C₁₅H₁₂F₃NO₃S 
• 130481-19-5 N-(1-Phenyl-1-trifluoromethyl-but-3-enyl)-hydroxylamine 
• 161864-19-3 2,2,2-trifluoroacetophenone O-(2-bromoethyl)oxime 
• 40618-96-0 3-phenyl-3-(trifluoromethyl)diaziridine 
• 434-45-7 2,2,2-Trifluoroacetophenone 

Relevant articles and documents

Photochemical Cyclopropenation of Alkynes with Diazirines as Carbene Precursors in Continuous Flow

An efficient synthesis of 3-trifluoromethyl-3-aryl-cyclopropenes via the cyclopropenation reaction of alkynes with photolytically generated carbenes from diazirine compounds is described. This reaction is performed in continuous flow using readily available LEDs under mild reaction conditions. This new and efficient method describes the synthesis of 25 examples of 3-trifluoromethyl-3-aryl-cyclopropenes with yields up to 97%, achieved in continuous flow with a 5 min residence time. Control experiments highlighted that diazirines are more efficient than diazo compounds for this transformation.

Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors

NLRP3 inflammasome mediated release of interleukin-1β (IL-1β) has been implicated in various diseases. In this study, rationally designed mimics of sulfonylurea moiety were investigated as NLRP3 inhibitors. Our results culminated into discovery of series of unprecedented N-cyano sulfoximineurea derivatives as potent NLRP3 inflammasome inhibitors. Compound 15 (IC50 = 7 nM) and analogues were found to be highly potent and selective NLRP3 inflammasome inhibitor with good pharmacokinetic profile. These effects translate in vivo, as 15, 29, and 34 significantly inhibit NLRP3 dependent IL-1β secretion in mice.

PROCESSES AND COMPOUNDS FOR THE DECARBOXYLATIVE AMINATION OF REDOX-ACTIVE ESTERS WITH DIAZIRINES

The invention described herein relates generally to processes for the synthesis of amine-containing organic compounds. More specifically, described herein relates to processes for the decarboxylative amination of redox-active esters with diazirines and the products formed thereof. Compounds for use in the above processes are also described.